针对手术切除的食道癌症的术后多学科治疗的最新情况
Takayuki Tsuji1, Satoru Matsuda1, Masashi Takeuchi1
1Department of Surgery, Keio University School of Medicine Tokyo, Japan.
Japanese journal of clinical oncology
|June 7, 2023
概括
食道癌治疗正在迅速发展,新疗法如新辅助化疗和免疫疗法显示出更好的生存率. 个性化治疗策略对于食道癌患者的更好的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床试验 临床试验
背景情况:
- 由于早期的转移和治疗挑战,食道癌的预后不好.
- 在西方社会,标准治疗是新辅助化学放射治疗 (CROSS试验).
- 最近的试验表明,新辅助三重化疗 (JCOG1109) 和辅助免疫疗法 (CheckMate-577) 的生存益处更大.
研究的目的:
- 审查食道癌症治疗的最新进展.
- 突出临床试验对管理策略的影响.
- 强调免疫疗法和个性化医学的作用.
主要方法:
- 关键临床试验的综述 (CROSS,JCOG1109,CheckMate-577,JCOG1804E,SANO). 这些临床试验主要包括:
- 讨论新辅助,辅助和最终治疗方法.
- 免疫疗法和器官保存策略的探索.
主要成果:
- 新辅助化学放射治疗在西方是标准的.
- 新辅助三重化疗和辅助免疫疗法改善了生存率.
- 目前正在进行的试验正在调查新的组合和积极监测.
结论:
- 食道癌的治疗有了显著的进步,特别是免疫疗法.
- 需要个性化的多学科治疗策略,包括生物标志物.
- 未来的研究重点是优化治疗和探索器官保存.
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