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婴儿期体重增加的遗传性:一个基于人口的双胞胎研究
Masha Krichevski1,2, Ronit Calderon-Margalit1, Shai Carmi1
1Braun School of Public Health and Community Medicine, The Hebrew University of Jerusalem - Hadassah, Jerusalem, Israel.
Paediatric and perinatal epidemiology
|June 7, 2023
概括
婴儿体重增加的遗传性在生命的第二年是最低的,为儿童肥胖干预提供了一个关键的窗口. 这个时期允许有针对性的策略来减轻与婴儿快速体重增加相关的风险.
科学领域:
- 儿科健康 儿科健康
- 遗传学 遗传学 是一个
- 肥胖问题研究研究
背景情况:
- 婴儿快速体重增加预示着儿童肥胖.
- 遗传和环境因素影响婴儿体重.
- 确定低遗传性时期有助于针对性干预.
研究的目的:
- 估计婴儿体重增加的遗传性.
- 分析从出生到18个月的体重增加.
- 利用以色列大规模的人类测量数据.
主要方法:
- 基于人口的双胞胎研究设计.
- 从9388对双胞胎 (2011-2015) 中提取了体重数据.
- 用双胞胎的性作为一个代理的zygosity.
主要成果:
- 出生体重的遗传性是最低的 (h2=0.40 ± 0.11).
- 体重增加的遗传性在4个月达到顶峰 (h2=0.87 ± 0.13).
- 在12-18个月间隔内,遗传能力显著下降 (h2=0.43 ± 0.16).
结论:
- 婴儿体重增加的遗传性在第二年下降.
- 生命的第二年是适合肥胖干预的.
- 有针对性的干预措施可以解决儿童肥胖风险.
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