[ursodeoxycholic acid-berberine超分子纳米颗粒对性结肠炎的治疗效果基于由弱键诱导的超分子系统]
Shan Gao1, Feng Gao1, Jing-Wei Kong2
1School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
概括
这项研究开发了UDCA-BBR超分子纳米颗粒来治疗性结肠炎 (UC). 这些纳米粒子在小鼠模型中有效降低了炎症并改善了症状,优于传统混合物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
- 胃肠病学 胃肠病学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 传统的中医药,如Coptidis Rhizoma和Bovis Calculus已经用于UC.
- 柏柏林 (BBR) 和 Ursodeoxycholic 酸 (UDCA) 是具有治疗潜力的关键活性成分.
研究的目的:
- 为了创建UDCA-BBR超分子纳米颗粒用于增强UC治疗.
- 描述纳米粒子的结构,特性和形成机制.
- 在急性UC小鼠模型中评估这些纳米颗粒的治疗疗效.
主要方法:
- 刺激的共过程合成UDCA-BBR超分子纳米颗粒.
- 使用FE-SEM,DLS,UV-Vis,光,IR,HR-MS和1H-NMR进行表征.
- 在小鼠中使用硫酸 (DSS) 诱导急性UC.
- 通过体重,结肠长度,DAI,血清细胞因子水平 (TNF-α,IL-6) 和中性粒细胞透来评估治疗效果.
主要成果:
- 成功合成了四面体UDCA-BBR超分子纳米粒子 (180nm).
- 纳米粒子的形成是由BBR和UDCA之间的静电吸引和疏水相互作用驱动的.
- 这些纳米粒子表现出持续释放和pH敏感性质.
- 与机械混合物相比,UDCA-BBR纳米颗粒显著改善了UC症状,减少了炎症标志物 (TNF-α,IL-6) 和减少了中性粒细胞的招募.
- 这些改善在统计学上是显著的 (P<0.001).
结论:
- UDCA-BBR超分子纳米颗粒为治疗性结肠炎提供了一个有前途的策略.
- 纳米粒子配方增强了BBR和UDCA的治疗效果.
- 这项研究为改善纳米药物输送系统中传统中医成分的吸收和疗效提供了一种新的方法.
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