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使用三种衍生试剂对八种氨基因丹进行GC-MS分析

Amber R Rose¹, Monica Joshi², Marianne E Staretz¹

¹Forensic Science Program, Department of Chemical, Physical, & Forensic Sciences, Cedar Crest College, Allentown, Pennsylvania, USA.

Journal of forensic sciences

|June 7, 2023

概括

使用MBTFA,HFBA和ECF的衍生技术成功地通过GC-MS识别了包括异构体在内的八种氨基因丹. 这种方法增强了对新型精神活性物质的法医分析.

科学领域:

法医化学法医化学
分析化学分析化学
毒理学毒理学毒理学

背景情况:

新型精神活性物质 (NPSs),特别是氨基因丹,越来越普遍.
气色谱-质谱 (GC-MS) 对于识别被扣押的毒品至关重要.
一些氨基氨基胺表现出类似的质谱数据,需要先进的分离技术.

研究的目的:

研究用于改进GC-MS分析氨基胺的衍生技术.
为法医实验室提供精确识别这些NPS的选项.
为了增强色谱分离和氨基胺的质谱表征.

主要方法:

对三种衍生试剂的评估:N-甲基双三乙胺 (MBTFA),六黄油无水化物 (HFBA) 和乙基酸盐 (ECF).
在Rxi®-5Sil MS和Rxi®-1Sil MS静止阶段使用GC-MS对八种氨基氨基的分析.
衍生与非衍生氨基色谱和光谱数据的比较.

主要成果:

这三种衍生方法均成功分离并鉴定出八种氨基双,包括像4,5-MDAI和5,6-MDAI这样的异构体.
衍生化减少了峰值尾部和增加了分析物丰度,改善了GC-MS检测.
衍生物产生了独特的碎片离子,有助于氨基因达的表征,尽管同位素4,5-MDAI和5,6-MDAI仅以保留时间区分.

结论:

衍生是一种有效的策略,用于GC-MS识别具有挑战性的氨基因丹.
MBTFA,HFBA和ECF为法医实验室提供了可行的选择,以增强氨基分析.
这些方法在识别法医案例工作中遇到的NPS时提供了灵活性和更高的准确性.

关键词:

氨基酸中的氨基酸.衍生化的衍生化药物分析药物分析气体染色学-质谱学和GCMS.新型精神活性物质是一种新型精神活性物质.

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