抗癌效应的抗癌作用
Saranya Varadarajan1, Balaji Thodur Madapusi2, Malathi Narasimhan3
1Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, Tamil Nadu, India, Phone: +91 9884748487,
The journal of contemporary dental practice
|June 7, 2023
概括
卡里卡·帕帕亚 (Carica papaya L.) 的叶子和种子,以及基异硫酸,对口腔状细胞癌 (OSCC) 具有抗癌作用. 不同的植物部位和性别对癌细胞周期和亡产生不同的影响.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 自然产品,包括Carica papaya L. (木瓜),越来越多地被研究其治疗潜力.
- 识别新型抗癌药物对于改善治疗结果至关重要.
研究的目的:
- 为了评估Carica papaya L.提取物 (叶子和种子) 和二酸的抗癌性质.
- 为了比较雄性和雌性木瓜植物提取物对口腔癌细胞的影响.
- 调查作用的潜在机制,包括细胞亡和细胞循环调节.
主要方法:
- 准备和量化基异硫酸和种子和叶子的类分离物.
- 用各种提取物和化合物治疗SCC-25口腔癌细胞系.
- 使用MTT测定,细胞灭亡分析,细胞周期分析和线粒体膜潜能测定来评估抗癌效应.
主要成果:
- 番茄种子的乙醇:水提取物产生了最高的二二酸的度.
- 与雌性叶相比,雄性木瓜叶含有更高的化物水平.
- 番茄叶和种子提取物诱导了细胞亡和细胞周期差异性停止 (雄性叶的S阶段,雌性叶和种子的G2M阶段).
结论:
- 卡里卡 L. 提取物和基异硫酸对OSCC具有显著的抗癌活性.
- 在雄性和雌性叶提取物之间观察到明显的抗癌作用.
- 番茄衍生化合物作为口腔癌的辅助疗法具有前景,可能改善患者的预后并减少复发.
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