奎尔丁对母胎界面的免疫调节的影响
Zhujing Fu1, Ye Tian2, Xuanle Zhou3
1Department of TCM Gynecology, Hangzhou Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China. 202011120911159@zcmu.edu.cn.
概括
在TCM草药中发现的奎尔素通过平衡母胎免疫力来保护怀孕. 它调节免疫细胞并减少炎症,为复发性自发性流产提供了潜在的治疗方法.
科学领域:
- 生殖免疫学 生殖免疫学
- 传统中国医学 (TCM) 是一种
- 药理学 药理学是指药理学的学科.
背景情况:
- 母胎界面的免疫平衡对于成功怀孕至关重要.
- 这种接口中的不平衡与不良妊娠结果有关.
- 奎尔素是TCM草药中的一种黄类物质,在怀孕期间表现出保护作用.
研究的目的:
- 审查奎尔素在调节母胎界面免疫中的作用和分子机制.
- 为治疗不良妊娠结果提供参考,如复发性自发性流产.
主要方法:
- 关于奎尔塞丁对母胎免疫细胞和组织的影响研究的文献综述.
- 对奎尔丁的抗炎,抗氧化和雌激素类似性能的分析.
- 检查氨酸对细胞因子和细胞功能在母胎界面的影响.
主要成果:
- 奎瑞调节免疫细胞 (例如NK细胞,巨细胞,T细胞,DC细胞,MDSC细胞),热囊细胞和层细胞.
- 它表现出抗炎,抗氧化和类似雌激素的活动.
- 奎尔赛丁减轻细胞毒性,减少细胞亡,并抑制过度的炎症.
结论:
- 奎尔素有助于维持母胎免疫平衡.
- 它的免疫调节作用表明,它对反复发生的自发流产和其他不良妊娠结果具有治疗潜力.
相关概念视频
Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
Development of Immunocompetence
366
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
366
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
354
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
354


