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的相互作用的相互作用.

Shuli Guo1,2, Xiandao Luo3, Xiaoyu Yin4

  • 1School of Public Health, Hangzhou Normal University, Hangzhou 311100, China. guoshuli@sina.cn.

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
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概括
此摘要是机器生成的。

身体质量指数 (BMI) 与维吾尔族缺血性心力衰竭 (IHF) 患者的HSP70-2基因多态相互作用. 低BMI (<26.5 kg/m2) 增加了HSP70-2AA/AG基因型的IHF患者预后不佳的风险.

关键词:
酒精消费 酒精消费 酒精消费体重指数 (Body Mass Index) 是一个指数.这就是HSP70-2基因.互动 互动 互动 互动缺血性心力衰竭是因为缺血性心力衰竭.

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科学领域:

  • 遗传学和基因组学 遗传学和基因组学
  • 心血管医学 心血管医学
  • 代谢健康 代谢健康

背景情况:

  • 缺血性心力衰竭 (IHF) 对健康构成重大负担,特别是在特定的种族群体中.
  • 遗传因素,如热冲击蛋白70-2 (HSP70-2) 基因多态,可能会影响IHF易感性和预后.
  • 包括体重指数 (BMI) 和酒精消费在内的生活方式因素已知是导致心血管疾病的因素.

研究的目的:

  • 研究HSP70-2基因多态,BMI和酒精消费对被诊断患有IHF的维吾尔族患者预后的相互作用影响.
  • 确定特定的遗传和生活方式风险因素,与IHF患者的不良结果相关.

主要方法:

  • 一项涉及205名维吾尔族IHF患者和200名健康对照者的病例控制研究.
  • 使用聚合酶链反应 (PCR) 分析HSP70-2基因+1267多态性.
  • 使用多变量逻辑回归和交叉分析 (计算相对过度相互作用风险 - - RERI) 来评估风险因素和相互作用.

主要成果:

  • IHF患者的不良预后与较高的酒精消费率,异常的肝酶 (ALT,AST),较低的BMI和左心室射出分数的减少有关.
  • 在良好的和不良的预后组之间以及不同NYHA心脏功能类别之间观察到HSP70-2基因型和等位基因频率的显著差异.
  • 在BMI和HSP70-2基因多态性 (RERI=1.15,P<0.01) 之间发现了显著的添加相互作用. 具体来说,BMI < 26.5 kg/m2 增加了 HSP70-2 AA/AG 基因型 (OR=7.47,P<0.01) 的患者预后不良的风险.

结论:

  • HSP70-2基因多态性与维吾尔族IHF患者的BMI相互作用.
  • 低于26.5kg/m2的BMI是携带HSP70-2AA/AG基因型的IHF患者预后不佳的重要危险因素.
  • 关于IHF预后,酒精消费与HSP70-2基因多态性没有显著的相互作用.