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系统性红斑狼中偏头痛的发生率:一个元分析

Surjyapratap Sarangi¹, Suraj K Nahak¹, Anisha Rupashree²

¹Department of Biotechnology, Berhampur University, Berhampur, India.

|June 7, 2023

概括

系统性红斑狼 (SLE) 患者的偏头痛总流行率为34.8%. 这一元分析证实偏头痛在SLE患者中比在健康人群中更为常见.

科学领域:

类风湿病学类风湿病学
神经学神经学
流行病学流行病学

背景情况:

系统性红斑狼 (SLE) 是一种自身免疫性疾病,临床表现不同,经常涉及神经复杂症.
偏头痛是SLE患者常见的神经症状,尽管其全球流行率和与SLE相关性需要进一步调查.
现有的研究表明,SLE患者的偏头痛发病率各不相同,这促使进行了全面的元分析,以澄清全球流行率和比较频率.

研究的目的:

确定在被诊断患有系统性红斑狼 (SLE) 的患者中偏头痛的全球患病率.
为了调查偏头痛是否在SLE患者中比健康对照患者更频繁地发生.
分析SLE人口中偏头痛发病率的潜在区域差异.

主要方法:

在主要数据库 (Scopus,PubMed,Science Direct,Google Scholar) 进行了系统的文献搜索,截至2023年1月21日.
用全面的元分析软件v3进行了元分析,评估与科克兰Q统计和I2值的异质性.
使用埃格尔的回归分析和漏斗图,评估了出版偏差.

主要成果:

分析包括17份报告,包括2901名SLE患者和575名健康对照,显示SLE患者的整体偏头痛患病率为34.8%.
与健康对照人群相比,SLE患者中偏头痛的发生率明显高 (OR: 1.964,p = 0.000).
亚组分析表明,南美洲的SLE患者中偏头痛的患病率明显较高 (56.2%).

结论:

全球大约三分之一的系统性狼患者患有偏头痛.
这些发现强烈表明,偏头痛是SLE患者比一般健康人群更频繁的并发症.

关键词:

系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.这是一个元分析.偏头痛偏头痛偏头痛偏头痛全球范围内的流行率.

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