种族中立方程用于评估患有沙拉血病的儿童的肺功能
Marwa Moaaz1, Omneya Badreldin2, Yasmine El Chazli3
1Department of Human Physiology, Clinical Respiratory Physiology Unit, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Pediatric pulmonology
|June 7, 2023
概括
肺功能障碍,特别是限制性螺旋测量模式,在患有输血依赖性沙拉西米亚 (TDT) 的儿童中很常见. 高血清费里水平是最强的预测因素,突出显示TDT患者肺功能监测的必要性.
科学领域:
- 儿科肺病学 儿科肺病学
- 血液学 血液学 血液学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 输血依赖性血症 (TDT) 是一种需要定期输血的慢性疾病.
- 肺功能障碍可能是TDT儿童的并发症.
- 精确评估肺功能对于管理TDT患者至关重要.
研究的目的:
- 用GLI 2022参考方程评估TDT儿童的肺功能障碍.
- 在这个儿科群体中确定肺功能障碍的关键预测因子.
- 用GLI 2012和GLI 2022方程来比较限制性模式的流行情况.
主要方法:
- 对68名TDT儿童和68名健康对照进行了螺旋测量.
- 使用GLI 2012 (高加索) 和GLI 2022 (全球) 参考方程分析了肺功能数据.
- 统计分析发现了螺旋计参数和临床/实验室数据之间的关联.
主要成果:
- 患有TDT的儿童表现出明显较低的FVC和FEV1,限制性模式的流行率为23.53%.
- 年龄较大,输血持续时间较长,体重指数z分数较低,血清费里含量较高与限制性模式有关.
- 高血清费里是限制性螺旋计最强的预测因子,即使在无症状儿童中也是如此.
结论:
- 与2012年GLI相比,GLI 2022方程降低了与GLI相比,限制性肺功能障碍的报告流行率,而不会影响患者的长期结果.
- 建议在TDT患者的常规监测中进行肺功能测试,特别是年龄较大的儿童和铁过载患者.
- 限制性螺旋测量模式在TDT儿童中普遍存在,这强调了早期检测和管理铁过载的重要性.
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