泰国在人类牙纸细胞中的体外抗炎作用
Nutthapong Kantrong1, Jittranut Kumtawee1, Teerasak Damrongrungruang2
1Khon Kaen University, Faculty of Dentistry, Department of Restorative Dentistry, Khon Kaen, Thailand.
Journal of applied oral science : revista FOB
|June 7, 2023
概括
泰国 прополис提取物显示出抗炎作用,通过抑制COX-2和PGE2.2来抑制脉炎症. 这种天然剂作为治疗性纸封盖材料具有前景.
科学领域:
- 生物材料科学 生物材料科学
- 牙科药理学 牙科药理学
- 免疫学 免疫学 免疫学
背景情况:
- 牙纸感染可能导致炎症,需要有效的治疗剂.
- 纸封闭旨在保持纸活力并促进愈合.
- 天然提取物正在牙科中探索它们的治疗潜力.
研究的目的:
- 调查泰国提取物作为潜在的纸封闭剂.
- 评估 прополис提取物对人类牙纸细胞中阿拉基酸通路的抗炎作用.
- 确定涉及插白素 (IL) - 1β刺激的作用机制.
主要方法:
- 人类牙纸细胞用IL-1β和不同度的 прополис提取物进行了治疗.
- 分析了mRNA和5-lipoxygenase (5-LOX) 和cyclooxygenase-2 (COX-2) 的蛋白质表达.
- 评估了前列腺素E2 (PGE2) 水平和核因子kappaB (NF-kB) 的激活.
主要成果:
- IL-1β刺激了COX-2,而不是5-LOX,并增加了PGE2水平.
- прополис提取物显著抑制了COX-2 mRNA和蛋白质的表达 (p<0.05).
- 提取物降低了PGE2水平,并阻止了NF-kB的核转移.
结论:
- 泰国提取物通过抑制COX-2和PGE2合成,表现出抗炎性质.
- 提取物通过抑制NF-kB通路而起作用.
- 泰国 прополис提取物是由于其抗炎作用而成为纸封装材料的有希望的候选物.
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