在产前接触大麻后儿童的神经发育结果
Oliver G Isik1, Ling Guo1, Andrew J O Whitehouse2
1Department of Anesthesiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Paediatric and perinatal epidemiology
|June 7, 2023
概括
产前大麻暴露 (PME) 没有影响儿童的神经发育或增加晚年自闭症风险. 这项研究发现,在怀孕期间接触大麻的儿童的认知或行为结果没有显著差异.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 产前大麻暴露 (PME) 对儿童神经发育的影响尚不清楚,之前的研究产生了不一致的结果.
- 了解这些影响对于公共卫生指导和家长咨询至关重要.
研究的目的:
- 为了研究 PME 和神经心理测试分数在儿童后期和成年早期之间的关联.
- 考虑一系列的父母特征和潜在的混因素.
主要方法:
- 利用了来自雷恩研究队列的数据 (n=2868).
- 使用倾向分数对暴露和未暴露儿童进行匹配,并使用反向概率审查权重 (IPCW) 对共变量进行调整.
- 评估结果包括不同年龄段的语言,行为,认知能力和自闭症特征.
主要成果:
- 在临床语言基础评估 (CELF) 评分中,暴露和未暴露的儿童之间没有发现显著差异.
- 产前大麻暴露与二次神经心理结果或临床缺陷风险增加无关.
- 在对共变量进行调整后,19-20岁的自闭症特征也显示没有与 PME 的关联.
结论:
- 产前大麻暴露似乎与儿童期的不良神经心理结果或成年早期的自闭症特征无关.
- 结果表明,在控制混因素后,PME可能不会显著影响神经发育轨迹.
更多相关视频
相关概念视频
Attention-Deficit/Hyperactivity Disorder
133
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
133
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K


