在动脉和静脉血栓封闭性疾病中) 起作用
Monika Zdanyte1,2, Oliver Borst1,2, Patrick Münzer1,2
1DFG Heisenberg Group Thrombocardiology, Eberhard Karl University Tübingen, Tübingen, Germany.
Frontiers in cardiovascular medicine
|June 7, 2023
概括
中性细胞外细胞陷 (NETosis) 通过释放炎症因子来驱动血栓封闭性疾病. 这篇评论探讨了NETosis的情况.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 中性细胞外细胞陷 (NETosis) 涉及释放脱凝的染色质和炎症因素,在血栓封闭性疾病中至关重要.
- 网症会影响血小板,白细胞和内皮细胞,导致静脉血栓栓塞和动脉动脉栓塞.
研究的目的:
- 审查心血管血栓封闭性疾病中NETosis的翻译和临床相关性.
- 讨论NETosis在动脉样硬化和静脉血栓闭塞性疾病的慢性和急性设置中的作用.
主要方法:
- 审查中性粒细胞生理学和NETosis的分子机制.
- 讨论NETosis在静脉和动脉血栓封闭性疾病中的作用.
- 考虑NET相关疾病的潜在预防和治疗策略.
主要成果:
- NETosis与深静脉血栓塞,肺栓塞,动脉样硬化,心肌梗塞和缺血性中风有关.
- NET在慢性和急性心血管血栓封闭事件中起着重要作用.
结论:
- NETosis是心血管血栓封闭性疾病的关键因素,需要进一步研究预防和治疗.
- 了解NETosis机制为管理这些疾病提供了潜在的治疗点.
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