接种COVID-19疫苗后的急性病:单中心回顾性研究
Chien-Chou Chen1, Sung-Sen Yang1, Yu-Juei Hsu1
1Division of Nephrology, Department of Medicine, National Defense Medical Center, Tri-Service General Hospital, Taipei, Taiwan.
Frontiers in medicine
|June 7, 2023
概括
接种COVID-19疫苗很少会导致急性病 (AKD). 这项研究在27名接种疫苗后的患者中发现了AKD,球体疾病和慢性病进展是常见的结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 报道称,COVID-19疫苗接种后的脏疾病正在增加.
- 这项研究调查了COVID-19疫苗接种后急性病 (AKD) 的发生率,原因和结果.
研究的目的:
- 为了确定COVID-19疫苗接种后AKD的发病率和病因.
- 在接种疫苗的人群中分析AKD的临床特征和结果.
主要方法:
- 来自单一医疗中心 (2021年3月至2022年4月) 接种COVID-19后AKD疫苗的成年患者的回顾性分析.
- 使用Naranjo分数评估因果关系;其他原因被同行脏病学家排除.
- 研究了AKD的病因,特征和结果.
主要成果:
- 27名患者在接种疫苗后出现了AKD,其中大多数人接受了mRNA疫苗.
- 常见的AKD病因包括淋巴细胞疾病 (IgA脏病,AAN,膜性GN,最小变化疾病) 和慢性病 (CKD) 的急性恶化.
- 六名患者在42周的中位随访期间进展到末期病 (ESKD).
结论:
- 接种COVID-19疫苗可能与AKD有关,特别是质隆炎.
- 高风险的CKD患者,特别是那些接受多剂量治疗的患者,可能面临更高的风险.
- 新生抗中性粒细胞质抗体相关的血球蛋白炎 (AAN),外表现,或先前存在的CKD表明的预后较差.
相关概念视频
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
40
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
40
01:29Acute Kidney Injury III: Clinical Manifestations
44
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
44
01:22Acute Kidney Injury I: Introduction
38
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
38
01:29Acute Kidney Injury II: Pathophysiology
37
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
37
01:26Kidney Transplant II: Surgical Procedure
37
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
37
01:28Kidney Transplant I: Introduction
29
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
29