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Aroop Mohanty¹, Ranjana Rohilla², Kamran Zaman³

¹Department of Microbiology, AIIMS Gorakhpur, Uttar Pradesh, India.

Le infezioni in medicina

|June 7, 2023

概括

疫苗衍生型脊髓灰质炎病毒 (VDPVs) 构成了全球消除脊髓灰质炎努力的挑战. 提高免疫率和探索更安全的疫苗替代品对于控制VDPV传播和实现无脊髓灰质炎世界至关重要.

科学领域:

病毒学病毒学
公共卫生公共卫生
免疫学免疫学免疫学

背景情况:

脊髓灰质炎是由脊髓灰质炎病毒,一种肠道病毒引起的.
疫苗衍生型脊髓灰质炎病毒 (VDPV) 从口服脊髓灰质炎病毒疫苗 (OPV) 中的活脊髓灰质炎病毒中产生.
视频脊髓灰质炎病毒的出现是消除脊髓灰质炎的重大全球挑战,近年来报告了数千例病例.

研究的目的:

突出VDPVs所带来的全球挑战.
讨论导致循环VDPV (cVDPV) 增加的因素.
建议控制VDPV传播和根除脊髓灰质炎的战略.

主要方法:

摘要没有详细说明具体的实验方法.
它依赖于报告的病例数量,并讨论了导致因素和潜在的策略.

主要成果:

在全球范围内,VDPV继续影响各种地区,在2020年有1000多例,在2021年有600多例.
诸如COVID-19大流行加剧的低疫苗接种率等因素,有助于cVDPVs的增加.
单价OPV (mOPV-2) 被确定为控制VDPV传播的潜在策略.

结论:

提高免疫率和更安全的疫苗替代品对于最大限度地降低VDPV风险至关重要.
持续警和对免疫计划的投资是全球脊髓灰质炎根除的必要条件.
实现无脊髓灰质炎的世界需要持续的全球努力.

关键词:

脊髓灰质炎病毒脊髓灰质炎病毒疫苗衍生型脊髓灰质炎病毒

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