基因预测的维生素C水平显著影响多种癌症类型的患者存活率和免疫型
Jing Yuan1, Yu-Hong Zhang1, Xin Hua2
1Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Frontiers in immunology
|June 7, 2023
概括
维生素C指数 (VCI) 与多种癌症的整体存活率和免疫特征相关. 这项研究表明,维生素C可能具有治疗潜力,特别是在结肠癌治疗中.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 观察性研究表明,维生素C可以降低癌症发病率和死亡率.
- 维生素C抗癌作用的潜在机制需要阐明.
- 需要进行全面的泛癌分析,以了解维生素C的预后和免疫关联.
研究的目的:
- 在不同癌症类型中调查维生素C指数 (VCI) 的预后价值.
- 探索VCI和瘤免疫微环境特征之间的关联.
- 在临床前癌症模型中验证维生素C的生物影响.
主要方法:
- 利用了来自20种癌症类型的5769名患者的癌症基因图谱基因表达数据.
- 根据预测维生素C水平的11个基因计算VCI,并将患者分为高/低VCI组.
- 使用Kaplan-Meier和ESTIMATE评估了VCI,整体存活率 (OS),瘤突变负担 (TMB),微卫星不稳定性 (MSI) 和免疫微环境之间的相关性.
主要成果:
- 在多种癌症中,VCI与预后有显著的相关性,特别是乳腺癌,头角状细胞癌,脏清细胞癌和直肠腺癌.
- VCI与改变的免疫型相关,并在癌症类型中与TMB和MSI有差异性关联.
- 在体内研究表明,维生素C抑制了结肠癌异种植的生长和调节的免疫细胞透.
结论:
- 维生素C指数 (VCI) 是多种癌症类型的显著预后生物标志物.
- 维生素C影响瘤免疫型,可能影响TMB和MSI.
- 维生素C具有治疗潜力,特别是在结肠癌中,需要进一步研究.
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