基于多参数磁共振成像的前列腺特异性抗原密度和PI-RADSv2得分有助于识别角前列腺癌
Cong Huang1,2,3, Rui Rui1,2,3, Ninghan Feng4,5
1Department of Urology, Peking University First Hospital, Beijing 100034, China.
Journal of Cancer
|June 7, 2023
概括
手术前的多参数核磁共振 (mpMRI) 可以识别激进的角前列腺癌 (APCa). 基于mpMRI的PSA密度和PI-RADSv2得分有助于进行急性前列腺切除术的患者进行手术规划.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 侵袭性角前列腺癌 (APCa) 在诊断和手术规划方面提出了挑战.
- 术前评估对于优化患者咨询和手术策略至关重要.
研究的目的:
- 评估手术前多参数磁共振成像 (mpMRI) 在检测侵袭性上角前列腺癌 (APCa) 的疗效.
- 评估mpMRI参数在指导进行激进前列腺切除术 (RP) 的患者手术决策中的实用性.
主要方法:
- 对662名经过激进前列腺切除术 (RP) 的患者进行了回顾性分析.
- 包括所有患者的手术前活检和mpMRI数据.
- 统计分析包括单变量,多变量和ROC分析,以确定APCa的预测因素.
主要成果:
- 在32.3%的患者中发现了侵袭性角前列腺癌 (APCa).
- 基于mpMRI的PSA密度 (PSAD) 和PI-RADSv2得分> 4是APCa的独立预测.
- 基于mpMRI的PSAD和PI-RADSv2得分的AUC值分别为0.646和0.612.
结论:
- 手术前的mpMRI,特别是PSAD和PI-RADSv2得分,可以有效地识别侵略性的顶端前列腺癌 (APCa).
- 这些mpMRI指标可以显著帮助进行激进前列腺切除术 (RP) 的手术决策.
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