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格拉布里丁抑制了携带ICE的多素耐药肠道细菌的传播

Jiafang Fu^1,2, Yayu Liu^1,2, Fengtian Wang³

¹First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Frontiers in microbiology

|June 7, 2023

概括

在Morganella morganii中发现了一种新型的整合和结合元件 (ICE),ICEMmoMP63,它赋予了多素耐药性. 这种ICE可以在细菌之间转移,而格拉布里丁可能会抑制多素耐药性.

科学领域:

微生物学微生物学
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

整合性和结合性元素 (ICE) 是移动性遗传元素,在 Morganella morganii.中对抗生素耐药性起到很大程度上未知的作用.
聚米辛耐药性是一个日益严重的公共卫生问题,需要对其遗传基础进行研究.

研究的目的:

调查M. morganii中发现的一种ICE对多素耐药性的贡献.
确定由ICE授予的抗生素耐药性的可转移性和机制.

主要方法:

用全基因组测序和生物信息学分析来识别ICE和抗生素耐药性基因.
在大肠杆菌中进行了结合试验和异质表达,以评估ICE的可转移性和功能.
确定了最小的抑制度,并对传统中医药图书馆进行了排泄抑制剂的选.

主要成果:

一种ICE,被指定为ICEMmoMP63,被确定并证实可以在Enterobacteriaceae中水平转移.
在ICEMmoMP63上发现了一种基因 (G3577_03020),可以调解多种抗生素耐药性,特别是对多菌素的耐药性.
天然化合物格拉布里丁 (glabridin) 显示出对多素耐药性的抑制作用.

结论:

由于其在抗生素耐药性中的作用,监测ICEMmoMP63在肠杆菌群中的传播至关重要.
与格拉布里丁和聚米辛的联合治疗显示出治疗由携带ICEMmoMP63.3的多药耐药细菌引起的感染的潜力.

关键词:

在MFS中,运输商是MFS运输商.莫尔加内拉·莫尔加尼 (Morganella morganii) 是一个来自摩尔加尼的动物.格拉布里丁 (Glabridin) 是一种可怕的药物.整合和结合元素的整合和结合元素.聚氨酸耐药性聚氨酸耐药性

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