在叶中改变肠道微生物群与焦虑障碍
Shouchao Wei1,2, Yingren Mai1,3, Li Hu4
1Department of Neurology, Central People's Hospital of Zhanjiang, Zhanjiang, China.
Frontiers in microbiology
|June 7, 2023
概括
患有叶和焦虑症 (TLEA) 的患者表现出肠道微生物群失调. 这项研究揭示了TLEA患者的细菌和真菌特征,为疾病机制和潜在的预防策略提供了洞察力.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 焦虑障碍经常与并发,特别是叶与焦虑 (TLEA).
- 肠道微生物群失调和TLEA之间的关系仍未得到充分研究.
- 了解肠道微生物组的变化对于TLEA的发病过程至关重要.
研究的目的:
- 为了研究TLEA患者的肠道细菌和真菌微生物群组成.
- 为了确定与TLEA相关的特定微生物种群.
- 探索影响TLEA肠道微生物群结构的因素.
主要方法:
- 在肠道微生物群样本中对细菌的16SrDNA和真菌的ITS-1区域进行高通量测序.
- 对51名TLEA患者 (细菌) 和45名TLEA患者 (真菌) 的样本进行了测序.
- 微生物群落的微差分析,从族群到属级别.
主要成果:
- TLEA患者表现出改变的肠道细菌形状,以增加的埃舍里希亚-西格拉和蛋白质细菌,并减少了克洛斯特里迪亚和菲尔米库特.
- 真菌分析显示,在TLEA患者中,Saccharomycetales和Ascomycota的丰度更高.
- 控制感知影响了细菌结构,而住院频率影响了真菌结构.
结论:
- 这项研究验证了TLEA中的肠道微生物群失调.
- 这些发现为了解TLEA的微生物基础提供了基础.
- 对细菌和真菌概况的进一步研究可能有助于预防TLEA相关的肠道失调.
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