吸烟是QuantiFERONTB黄金试验和结核病病因之间的不一致的一个因素:特别是在老年患者中
Libin Liu1,2, Guihua Wu1,2, Jing Wang1,2
1Centre of Laboratory Medicine, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Infection and drug resistance
|June 7, 2023
概括
吸烟会对结核病诊断的准确性产生负面影响. 吸烟者,特别是老年人,表现出干扰素 (IFN-γ) 释放的减少,导致与已确认的结核病因理相比,QuantiFERON-TB Gold测定 (QFT-GIT) 结果不一致.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 量子费隆-结核黄金试验 (QFT-GIT) 是诊断结核病 (TB) 的一个关键工具.
- QFT-GIT结果与确定的结核病病因学之间的不一致性可能会影响患者的治疗.
- 吸烟是一种普遍的行为,可能会对免疫反应产生影响.
研究的目的:
- 调查吸烟是否影响QFT-GIT结果与结核病病因学之间的不一致.
- 评估吸烟对结核病患者的干扰素- (IFN-γ) 水平的影响.
主要方法:
- 从接受QFT-GIT测试的Mycobacterium结核病 (MTB) 阳性患者的临床数据的回顾性分析.
- 吸烟者与非吸烟者之间的特征比较,使用基平方和等级和值测试.
- 后勤回归和倾向得分匹配 (PSM) 以调整混因素并验证结果.
主要成果:
- 不一致的QFT-GIT结果的整体发病率为8.90%,假负率为6.27%.
- 吸烟者表现出较低的基础IFN-γ水平 (P=0.038) 和,在老年人 (≥65岁),较低的抗原刺激IFN-γ水平 (P=0.005).
- 吸烟被确定为一个影响因素 (OR=1.69,P=0.020) 和一个独立的风险因素 (OR=1.95,P=0.019) 的QFT-GIT/TB病因异常,特别是在年龄≥65岁的患者 (OR=2.40,P=0.005).
结论:
- 吸烟会损害身体的IFN-γ释放能力.
- 吸烟是QFT-GIT和结核病病因学结果不一致的重要影响因素,特别是在老年人群中.
相关概念视频
01:26Pulmonary Tuberculosis IV
175
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
175
01:28Pulmonary Tuberculosis II
281
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
281
01:31Pulmonary Tuberculosis III
383
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
383
01:29Pulmonary Tuberculosis I
288
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
288
01:28Pulmonary Tuberculosis V
214
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
214
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K