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Updated: Jul 27, 2025

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Published on: December 27, 2010

(5R) -5-基三化物用于接受ART的HIV免疫不响应者:一种随机,双盲,安慰剂控制的II期随机研究

Wei Cao^1,2, Xiaosheng Liu^1,3,4, Yang Han¹

¹Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.

The Lancet regional health. Western Pacific

|June 7, 2023

概括

中国草药的衍生物LLDT-8显著改善了HIV抑制免疫不响应患者的CD4 T细胞数量. 这种治疗也减少了炎症,为这个患者群体提供了新的治疗选择.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
传染性疾病传染性疾病

背景情况:

对艾滋病毒抑制免疫不响应者 (INRs) 的治疗策略尚未得到充分确立.
之前的研究表明Tripterygium wilfordii Hook F在INR中的有效性.
这项研究评估了其衍生物LLDT-8对CD4 T细胞恢复的影响.

研究的目的:

评估LLDT-8在改善INR中CD4T细胞计数方面的疗效和安全性.
评估LLDT-8对该群体炎症标志物的影响.
为INRs提供潜在的新治疗选择.

主要方法:

一个二期,双盲,随机,安慰剂对照试验在中国进行.
长期抑制艾滋病毒和低于最佳的CD4恢复的149名成年患者被纳入.
参与者接受了口服LLDT-8 (0.5毫克或1毫克每天) 或安慰剂48周与抗逆转录病毒治疗一起.

主要成果:

与安慰剂相比,LLDT-8治疗,特别是每天1毫克,显著增加了CD4 T细胞计数 (p=0.036).
更高剂量的LLDT-8导致血清干扰素-γ诱导的蛋白10水平显著降低 (p=0.007).
LLDT-8耐受性良好,没有报告与药物相关的严重不良事件.

结论:

在INR中,LLDT-8显示出作为增强CD4 T细胞恢复的治疗剂的潜力.
该化合物有效地减轻了这个患者群体的炎症.
LLDT-8为艾滋病毒感染者和免疫不响应患者提供了一个有前途的新治疗途径.

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