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[] 现在的情况是.

Zhenfeng Liu1, Guanghua Wen2, Yuqiao Huang3

  • 1Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in oncology
|June 7, 2023
PubMed
概括
此摘要是机器生成的。

这项研究开发了一种新的PET成像探针,[18F]AlF-NOTA-ADH-1,用于检测瘤中的N-cadherin表达. 该探测器在各种癌症模型中成功可视化了N-cadherin水平,显示了对非侵入性瘤评估的潜力.

关键词:
在EMT中,EMT是EMT.这是一种N-cadherin.皮肤成像探头PET成像探头[18 F]AlF-NOTA-ADH-1的使用情况癌症 癌症 癌症 癌症 癌症

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科学领域:

  • 核医学是一种核医学.
  • 在瘤学瘤学.
  • 放射化学 放射化学是指辐射化学.

背景情况:

  • N-cadherin 是一个关键的细胞粘附分子,也是各种癌症的治疗点.
  • N-cadherin对抗剂ADH-1显示出显著的抗瘤活性.
  • 开发针对N-cadherin的向成像剂对于癌症诊断和治疗监测至关重要.

研究的目的:

  • 开发和评估一种新型的正子发射断层扫描 (PET) 成像探针[18F]AlF-NOTA-ADH-1,用于N-cadherin.
  • 评估[18F]AlF-NOTA-ADH-1在向表达N-cadherin的瘤中的体外和体内性能.

主要方法:

  • [18F]AlF-NOTA-ADH-1的放射合成,其放射化学纯度高 (>97%).
  • 在实验室中使用N-cadherin表达 (SW480) 和低表达 (BXPC3) 癌细胞进行细胞结合试验.
  • 在患者衍生异种移植 (PDX) 和细胞系衍生瘤模型中的体内生物分布研究和微PET成像.
  • 免疫组织化学和阻断实验以确认N-cadherin的特异性.

主要成果:

  • 成功的放射合成产生了高达30%的[18F]AlF-NOTA-ADH-1.
  • 在体外研究证实了Cy3-ADH-1与N-cadherin阳性细胞的结合.
  • 在体内成像和生物分布显示,瘤中探针吸收率更高,N-cadherin表达更大,与免疫组织化学相关.
  • 阻断实验验证了探针的N-cadherin特定吸收.

结论:

  • [18F]AlF-NOTA-ADH-1在体外成功合成并证明了特定的N-cadherin向.
  • 该探测器通过微PET成像有效地可视化了瘤中的差异性N-cadherin表达.
  • 这些发现突显了[18F]AlF-NOTA-ADH-1作为PET成像剂的潜力,用于对瘤N-cadherin表达的非侵入性评估.