METS-VF能否提供关于结石形成的线索?
Zhenyu Guo1,2,3, Guoxiang Li1,2,3, Yan Chen4
1Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Frontiers in endocrinology
|June 7, 2023
概括
通过METS-VF测量的高内脏脂肪与患结石的风险增加有关. 这一发现表明,METS-VF可能是预防和管理结石的有用标志物.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 结石影响了14%的人口,肥胖,糖尿病和遗传等因素发挥了作用.
- 内脏脂肪积累是与各种代谢障碍相关的日益严重的健康问题.
- 了解结石的新风险因素对于有效的预防策略至关重要.
研究的目的:
- 调查高内脏脂肪得分 (METS-VF) 与结石的患病率和进展之间的关联.
- 探索METS-VF作为结石发育的预测标记物的潜力.
- 通过了解内脏脂肪的作用来确定结石的潜在预防措施.
主要方法:
- 分析了从2007年至2018年国家健康和营养检查调查 (NHANES) 的29,246名参与者的数据.
- 利用后勤回归,细分分析和剂量反应曲线分析来评估METS-VF和结石之间的关系.
- 根据性别,种族,血压和血糖水平进行了分组分析.
主要成果:
- 在METS-VF和结石的患病率和进展之间发现了显著的积极关联.
- 结石的几率比率 (ORs) 随着各种人口和健康子组的METS-VF较高而增加.
- 在不同性别,不同种族以及有或没有高血压和糖尿病的个体中观察到一致的关联.
结论:
- 高内脏脂肪分数 (METS-VF) 与结石的出现和进展密切相关.
- METS-VF可以作为一种有价值的生物标志物,用于识别患结石风险的个体.
- 对METS-VF的进一步研究可能会导致针对性干预,以预防和管理结石.
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