动态捕捉器用于稳定高粘度挤出喷气
R Bruce Doak1, Robert L Shoeman1, Alexander Gorel1
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany.
Journal of applied crystallography
|June 7, 2023
概括
一个新的旋转圆柱式集热器,或新的旋转圆柱式集热器.
科学领域:
- 晶体学 晶体学是指结晶学.
- 材料科学 材料科学 材料科学
- 生物物理学的生物物理.
背景情况:
- 序列X射线晶体学需要稳定地提供微晶体.
- 高粘度挤出注射方法经常受到自由喷射不稳定的影响.
- 现有的微晶输送方法可能很复杂或昂贵.
研究的目的:
- 开发一种简单而便宜的微晶输送装置.
- 为了减轻高粘度挤出注射中的不稳定性.
- 为了促进连续X射线晶体学的微晶体输送.
主要方法:
- 旋转圆柱式收集器 ("捕获器") 的设计和实施.
- 使用收集器在挤出注入过程中稳定自由喷气.
- 将设备与串行衍射X射线晶体学工作流程集成.
主要成果:
- 旋转集热器有效地减少了自由喷气的不稳定性.
- 从高粘度溶液中实现了稳定的微晶输送.
- 该设备的构造简单,实施成本低廉.
结论:
- 描述的捕获器是微晶输送挑战的实际解决方案.
- 这一创新提高了对粘性样品的连续X射线晶体学的可行性.
- 该设备提供了一种具有成本效益的方法来提高衍射数据质量.
相关概念视频
01:14Free Jet
201
Free jets describe the flow of liquid exiting a reservoir through an opening into the atmosphere without resistance. The velocity (v) of the liquid jet is derived using Bernoulli's principle and expressed as:
201
01:17Steady, Laminar Flow Between Parallel Plates
247
Understanding steady, laminar flow between parallel plates is essential for analyzing and designing flow in narrow rectangular channels, commonly found in various water conveyance and drainage systems. The Navier-Stokes equations govern fluid motion and are generally challenging to solve due to their nonlinearity. However, simplifications are possible in certain cases, like the steady laminar flow between parallel plates. For this scenario, we assume steady, incompressible, laminar flow.
247
01:23Steady, Laminar Flow in Circular Tubes
263
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is...
263
01:16Precipitate Formation and Particle Size Control
821
In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
821