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与免疫相关的不良事件与免疫治疗在非小细胞肺癌中的疗效之间的关联:元分析

Li Lin¹, Yu Liu², Chen Chen¹

¹Department of Oncology, Wuhan Asia General Hospital, Wuhan, China.

Frontiers in pharmacology

|June 7, 2023

概括

在接受免疫检查点抑制剂 (ICI) 治疗的非小细胞肺癌 (NSCLC) 患者中经历免疫相关不良事件 (irAEs) 与更好的抗瘤疗效和生存结果有关.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
临床研究临床研究

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了非小细胞肺癌 (NSCLC) 治疗.
了解免疫相关不良事件 (irAEs) 与治疗疗效之间的关系对于优化患者的治疗结果至关重要.

结论:

在接受ICI的NSCLC患者中,irrAEs的发生是生存有效性的强有力的预测指标.
患有特定irrAEs的患者,特别是多重事件,可能会获得更好的生存益处.

关键词:

临床疗效临床疗效免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.进行元分析.其他非小细胞肺癌.

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