维生素A:太好没有坏?
Guoxun Chen1, Sabine Weiskirchen2, Ralf Weiskirchen2
1College of Food Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, China.
Frontiers in pharmacology
|June 7, 2023
概括
维生素A对健康至关重要,但过少或过多都可能损害肝脏. 本综述探讨了维生素A生物学的复杂,未解决的问题及其对肝脏健康的影响.
科学领域:
- 营养科学 营养科学
- 生物化学 生物化学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 维生素A是一种必需的脂性微量营养素,对视力,细胞生长,繁殖和免疫力至关重要.
- 维生素A缺乏症 (维生素A缺乏症) 和过量摄入都会导致严重的健康问题,特别是影响肝脏.
- 肝脏在维生素A的储存,新陈代谢和平衡中发挥着中心作用,肝脏的星状细胞是主要的储存地点,参与炎症.
研究的目的:
- 审查和讨论了解维生素A生物学的有争议和未解决的问题.
- 突出肝脏对维生素A状况的关键反应,包括过量损伤和缺乏功能变化.
- 检查肝星细胞在维生素A稳态和肝炎中的多方面的作用.
主要方法:
- 文献综述和对维生素A代谢和功能现有研究的综合.
- 分析维生素A状态对肝脏形态和功能的影响.
- 在动物疾病模型中对不同维生素A水平的不同反应的探索.
主要成果:
- 维生素A缺乏和过量摄入都会导致严重的健康后果,特别是肝损伤,纤维化和肝功能改变.
- 肝星细胞是维生素A储存的关键参与者,并调节肝脏内的炎症反应.
- 观察到的不同动物疾病模型对维生素A状态的反应不一致表明了复杂的相互作用.
结论:
- 了解维生素A的生物学仍然很复杂,存在重大未解决的问题,特别是关于其对肝脏健康的影响.
- 进一步研究维生素A,动物基因组和表观遗传设置之间的相互作用是必要的,以澄清这些复杂性.
- 精确调节维生素A水平对于维持肝脏健康和整体生理功能至关重要.
更多相关视频
05:03Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
Published on: December 27, 2024
1.2K
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.7K
相关概念视频
01:30Vitamins
826
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
826
01:23Role of Skin in Vitamin D Synthesis
5.4K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.4K
01:25Role of Vitamins in Maintaining Bone Health
3.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.5K
01:31Lipid-derived Compounds in the Human Body
4.4K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
4.4K
01:27Effects of Chemicals: Overview
1.3K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.3K
01:22Connective Tissue Cell Types
3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K