长效注射剂及其口服或短效注射等效配方的住院处方模式
Yifei Liu1, Mark E Patterson1, Suman Sahil2
1Division of Pharmacy Practice and Administration, University of Missouri-Kansas City School of Pharmacy, Kansas City, MO, United States.
Frontiers in pharmacology
|June 7, 2023
概括
从2010年到2016年,长效注射 (LAI) 抗精神病药在医院的使用不足. 在此期间,第二代抗精神病药物LAI的处方,特别是帕利皮里棕酸,显著增加.
科学领域:
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 长效注射 (LAI) 抗精神病药 (APs) 提供治疗坚持的好处.
- 口服和短效注射 (SAI) 配方的APs是广泛可用的.
- 在特定人群之外,LAI及其等效的住院处方模式并未得到很好的描述.
研究的目的:
- 确定第一代 (FGA) 和第二代 (SGA) 抗精神病药物LAI及其口服/SAI配方的住院处方模式.
- 分析精神分裂症,精神分裂情绪障碍或双相情感障碍住院期间AP使用趋势.
主要方法:
- 使用Cerner健康事实®数据库 (2010-2016) 的回顾性研究.
- 鉴定了因精神分裂症,精神分裂情绪障碍或双相情感障碍而入院的病例.
- 定义AP利用率为住院住院的比例,其中至少使用了一种AP.
主要成果:
- 在94,989个确定的遭遇中,SGA LAI的口服/SAI是最常见的 (41%).
- FGA LAI或SGA LAI是最不常见的 (1.1%).
- 帕利佩里棕酸和利佩里占主导地位的SGA LAI使用,帕利佩里棕酸从30%增加到72%,而利佩里从70%降至18% (p < 0.001).
结论:
- 与口服或SAI配方相比,在2010年至2016年期间,LAI的使用量明显不足.
- 在SGA LAIs中观察到处方模式的显著变化,有利于帕利皮里顿棕酸盐而不是Risperidone.
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