分子蒸对抗炎活性和神经毒性的分子蒸的影响
Yang Liu1, Fang Wang1, HuiWen Guo2
1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, China.
Frontiers in pharmacology
|June 7, 2023
概括
分子蒸分离了Asarum精油 (AEO) 的成分,产生了一种具有强烈抗炎作用和降低毒性的轻微分量. 这种方法有助于确定更安全的AEO度用于治疗.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 阿萨鲁姆精油 (AEO) 具有抗炎和止痛的特性.
- 高剂量的AEO可以导致毒性.
- 识别特定的有毒和药理动力学成分对于安全应用至关重要.
研究的目的:
- 通过分子蒸 (MD) 来研究AEO的毒性和药学动力学成分.
- 评估AEO分量的抗炎和神经毒性作用.
- 在体内确定AEO及其分量的整体毒性.
主要方法:
- 分子蒸 (MD) 被用于分成AEO.
- 使用RAW264.7细胞评估了抗炎活性.
- 神经毒性被评估在PC12细胞和通过小鼠急性毒性测定.
主要成果:
- AEO主要含有沙夫罗尔,甲基尤根醇和3,5-二氧化硫.
- MD生产了三个分数,具有不同的挥发性化合物组成.
- 轻微分数显示出优越的抗炎活性和较低的毒性,与其他分数和原始油相比.
- 所有AEO样本在PC12细胞中都显示出神经毒性,异常细胞核,增加的亡,ROS和减少的SOD表明了这一点.
结论:
- 分子蒸是有效的分离和丰富AEO组件.
- AEO的轻微分量具有显著的抗炎作用潜力,毒性降低.
- MD技术有助于为潜在的治疗应用选择更安全的AEO度.
相关概念视频
Local Anesthetics: Adverse Effects
459
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
459
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
327
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
327
Antimicrobial Effectiveness
98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98


