干细胞衍生的外体细胞用于牙-肉复合体再生:一个迷你审查
Dina A Hammouda1, Alaa M Mansour1, Mahmoud A Saeed2
1Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Restorative dentistry & endodontics
|June 7, 2023
概括
外基因组显示出再生牙 - 纤维质复合体 (DPC) 的前景. 这些细胞外囊泡促进细胞生长,血管形成和免疫调节,有助于牙科应用中的组织修复.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 细胞生物学 细胞生物学
背景情况:
- 牙-肉复合物 (DPC) 的自我修复能力有限.
- 再生策略对于治疗DPC损伤至关重要.
- 作为细胞间通信的关键媒介,外体细胞正在成为强大的治疗药物.
研究的目的:
- 审查关于DPC再生中的外体体应用的当前文献.
- 阐明外部体促进DPC修复的机制.
- 评估外生体作为DPC再生的治疗工具的潜力.
主要方法:
- 在PubMed和Scopus数据库上进行了系统的文献搜索.
- 包括2013年1月1日至2023年1月1日之间发表的文章.
- 综合了体外和体内研究的结果.
主要成果:
- 外基因组通过特定的信号通路 (MAPK,Wnt) 增强间基因干细胞的增殖和迁移.
- 外体体表现出益血管效应,促进内皮细胞活动和新血管化.
- 外体细胞调节免疫反应,促进M2巨细胞的两极分化和Treg细胞的转化.
- 在体内研究表明,外体诱导的牙纤维状组织的再生,特别是那些在质条件下分离的.
结论:
- 外体是细胞过程的强有力的调节者,对于DPC再生至关重要.
- 在牙科学上隔离的外体细胞表现出增强的再生能力.
- 外体是牙-肉复合体再生的有希望的治疗途径,适用于轻微暴露和整个肉再生.
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