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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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干细胞衍生的外体细胞用于牙-肉复合体再生:一个迷你审查.

Dina A Hammouda1, Alaa M Mansour1, Mahmoud A Saeed2

  • 1Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

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外基因组显示出再生牙 - 纤维质复合体 (DPC) 的前景. 这些细胞外囊泡促进细胞生长,血管形成和免疫调节,有助于牙科应用中的组织修复.

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牙纸是一种牙纸.牙纸的封闭方式牙上的牙.外基因组是外基因组的组成部分.再生性内牙科是指再生性内牙科.干细胞是一种干细胞.

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科学领域:

  • 生物医学工程 生物医学工程
  • 再生医学是一种再生医学.
  • 细胞生物学 细胞生物学

背景情况:

  • 牙-肉复合物 (DPC) 的自我修复能力有限.
  • 再生策略对于治疗DPC损伤至关重要.
  • 作为细胞间通信的关键媒介,外体细胞正在成为强大的治疗药物.

研究的目的:

  • 审查关于DPC再生中的外体体应用的当前文献.
  • 阐明外部体促进DPC修复的机制.
  • 评估外生体作为DPC再生的治疗工具的潜力.

主要方法:

  • 在PubMed和Scopus数据库上进行了系统的文献搜索.
  • 包括2013年1月1日至2023年1月1日之间发表的文章.
  • 综合了体外和体内研究的结果.

主要成果:

  • 外基因组通过特定的信号通路 (MAPK,Wnt) 增强间基因干细胞的增殖和迁移.
  • 外体体表现出益血管效应,促进内皮细胞活动和新血管化.
  • 外体细胞调节免疫反应,促进M2巨细胞的两极分化和Treg细胞的转化.
  • 在体内研究表明,外体诱导的牙纤维状组织的再生,特别是那些在质条件下分离的.

结论:

  • 外体是细胞过程的强有力的调节者,对于DPC再生至关重要.
  • 在牙科学上隔离的外体细胞表现出增强的再生能力.
  • 外体是牙-肉复合体再生的有希望的治疗途径,适用于轻微暴露和整个肉再生.