慢性病患者多药耐药性尿路感染:一项观察性研究
A H M Sanjedul Haque Sumon1, Md Rashid Al-Mahmood2,3, Khaza Amirul Islam4
1Nephrology, Shaheed Ziaur Rahman Medical College Hospital, Bogura, BGD.
Cureus
|June 7, 2023
概括
多抗药性尿路感染 (MDR UTI) 在慢性病 (CKD) 患者中非常普遍. 基于尿液培养的细致抗生素选择对于管理MDR尿路感染在这个脆弱人群中至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
背景情况:
- 慢性病 (CKD) 患者容易发生尿路感染 (UTI).
- 多药耐药 (MDR) 生物体的增加在管理感染方面构成了重大挑战,特别是在像CKD患者这样的免疫受损人群中.
- 了解CKD患者的特定MDR模式对于有效的治疗策略至关重要.
研究的目的:
- 确定慢性病 (CKD) 患者多药耐药性 (MDR) 尿路感染 (UTIs) 的患病率.
- 在这个患者群体中确定导致尿路感染的细菌分离物的特定MDR模式.
主要方法:
- 在班加邦杜谢赫穆吉布医科大学 (Bangabandhu Sheikh Mujib Medical University) 进行了一项涉及326名被诊断为CKD患者的横截面研究.
- 数据收集包括半结构化问卷和尿样分析,用于生物体识别和抗生素敏感性测试.
- 用有目的的抽样来招募参与者.
主要成果:
- 研究人口主要为女性 (60.1%),并参加了门诊 (75.2%).
- 观察到MDR尿路感染的高患病率 (64.7%),其中最常见的隔离物是グラム阴性细菌 (79.4%),特别是大肠杆菌 (55.5%).
- 在常见的克拉姆阴性和克拉姆阳性分别分离物中,注意到对诺和氨基甘油酸的显著耐药性. 尿路感染史和抗生素摄入与MDR尿路感染有显著的关联.
结论:
- 在CKD患者中,MDR尿路感染的患病率相当高.
- 以尿液培养和敏感性测试为指导的适当的抗生素选择至关重要.
- 实施合理使用抗生素的指导方针对于管理和预防慢性病患者中MDR尿路感染的发展至关重要.
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