在患有肺动脉高血压的儿童中,肌肉力量降低
Shari Pepplinkhuizen1, Graziella Eshuis1, Willemijn M H Zijlstra1
1Department of Pediatric Cardiology, Center for Congenital Heart Disease, Beatrix Children's Hospital, University Medical Center Groningen University of Groningen Groningen The Netherlands.
患有肺动脉高血压 (PAH) 的儿童表现出显著减少的肌肉力量. 这种弱点与运动能力相关,但并非所有疾病严重性标志物,这表明PAH是一种全身综合征.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 肺高血压研究 肺高血压研究
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 已知肺动脉高血压 (PAH) 在成年人中降低肌肉力量.
- 在儿科患者中,PAH对肌肉强度的影响仍然不太清楚.
- 研究PAH儿童的肌肉功能对于全面了解该疾病的全身影响至关重要.
研究的目的:
- 评估和比较PAH儿童的肌肉力量与健康对照.
- 探索肌肉强度与PAH疾病严重程度的已确定的标志物之间的关系.
- 为了确定PAH是否会影响儿科患者的外周肌肉功能.
主要方法:
- 一项前性研究涉及18名被诊断患有PAH的儿童 (4-18岁).
- 肌肉强度通过手握强度和最大自愿同度收缩率 (MVIC) 来评估.
- 使用Bruininks-Oseretsky运动能力测试 (BOT-2) 评估的动态肌肉功能,与健康队伍相比.
主要成果:
- 与对照组相比,患有PAH的儿童的手握强度显著降低 (z-score -2.4),总MVIC (z-score -2.9) 和BOT-2得分 (z-score -1.0) 显著降低.
- 肌肉强度测量,特别是BOT-2,与6分钟步行距离 (6MWD) 有显著的相关性.
- 没有发现肌肉强度和N-终端亲脑性尿素 (NT-proBNP) 或诊断后的时间之间存在显著的相关性.
结论:
- 患有PAH的儿科患者在静态肌肉和动态肌肉力量方面表现出显著的减少.
- 患有PAH的儿童肌肉力量降低与运动能力 (6MWD) 有关,但与其他疾病严重程度指标不一致.
- 这些发现支持了认为PAH是一种系统性疾病,即使在儿科病例中也会影响外围骨肌肉.
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