运动诱导的血管新生被卡普托普里尔减弱,但在高血压大鼠中,在佩林多普里尔治疗下维持
Anderson G Macedo1,2, Danyelle S Miotto1,2, Lidieli P Tardelli1,2
1Department of Physical Education, School of Sciences, São Paulo State University, Bauru, Brazil.
Frontiers in physiology
|June 7, 2023
概括
与高血压大鼠中的卡普托普利尔相比,大普利尔更好地支持炼诱导的骨和心脏肌肉的血管生成. 这表明,对于参与有氧运动的高血压个体来说,大兴可能更可取.
科学领域:
- 运动生理学 运动生理学
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 运动促进血管生成,改善血液流动,减少血管阻力.
- 一些抗高血压药物可以干扰运动诱导的血管生成.
- 自发高血压大鼠 (SHR) 呈现出改变的血管新生反应.
研究的目的:
- 为了比较卡普托普里尔和百度普里尔对大鼠运动诱导的心脏和骨肌血管生成的影响.
- 研究这些药物对血压,毛细血管密度和关键血管生成因子 (VEGF,VEGFR-2, eNOS) 的影响.
主要方法:
- 威斯特老鼠和SHR接受了有氧训练或保持久坐状态60天.
- 在过去的45天里,老鼠接受了卡普托普里尔,佩林多普里尔或水 (对照组).
- 测量了血压,对前 (TA) 和左心室 (LV) 的组织学分析评估了毛细血管密度和蛋白质水平.
主要成果:
- 运动增加了Wistar大鼠的血管密度,由更高的VEGFR-2和eNOS介导.
- 这两种药物都减弱了Wistar大鼠的运动诱导血管新生,而大兴的减弱作用较小.
- 在SHR中,运动防止了TA肌肉的稀缺,而接受卡波普利尔治疗的老鼠与接受印普利尔治疗的老鼠相比显示出减弱的血管生成.
结论:
- 与SHR中的卡普托普利尔相比,大林多普利尔表现出更强的支持炼诱导的骨肌肉血管生成的能力.
- 这两种药物都有效地降低了SHR中的血压.
- 在高血压患者进行有氧运动时,因其对血管新生产生有利的影响,大兴可能是相对于卡波普里尔的首选选择.
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