相关实验视频
Updated: Jul 27, 2025

07:25
Transdermal Measurement of Glomerular Filtration Rate in Mice
Published on: October 21, 2018
22.0K
D-阿斯巴拉金是一种理想的内源分子,用于测量淋巴膜过率
Ayumu Taniguchi1, Masataka Kawamura1, Shinsuke Sakai2,3,4
1Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Kidney international reports
|June 7, 2023
概括
作为测量功能的一种新生物标志物,D-阿斯巴拉金显得有前途. 这项研究发现,d-阿斯巴拉金是膜过率 (GFR) 的可靠指标,其表现优于目前的标记物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 准确测量膜过率 (GFR) 的理想内源生物标志物仍然难以捉摸.
- 虽然d-氨酸已经显示出实用性,但对功能评估中优质内源标记物的搜索仍在继续.
- 这项研究研究了其他d-氨基酸作为功能指标的潜力.
研究的目的:
- 评估d-氨基酸作为内源生物标志物的潜力,用于GFR测量.
- 将d-氨基酸分泌比率的准确性和偏差与已建立的GFR标记器进行比较.
- 确定一种新的,可靠的内源分子来评估功能.
主要方法:
- 一项涉及207名移植捐赠者和接受者的横截面观察性研究.
- 用因素 (C-in) 清除率作为黄金标准来测量淋巴膜过率 (GFR).
- 使用多变量分析和德明回归来评估d-氨基酸水平,分量分泌 (FE) 和GFR之间的关联,分析C-in.
主要成果:
- 多变量分析确定了d-asparagine的血液水平作为GFR的重要指标.
- 与肌素 (147.93%) 和d-氨酸 (84.84%) 相比,d-氨酸的分量分泌率 (FEin) 为98.67%,显示出最小的偏差.
- 对于d-阿斯巴拉金清除与胰岛素清除的比例偏差为-7.8%,明显低于肌素 (-34.5%) 和d-素 (21.2%) 的偏差.
结论:
- D-阿斯巴拉金表现出与胰岛素相似的处理特征.
- D-阿斯巴拉金成为高精度内源分子,用于GFR测量.
- 这一发现将d-阿斯巴拉金定位为评估功能的潜在理想生物标志物.
关键词:
通过许可证的许可证.d-阿斯巴拉基因的使用方法在这种情况下,d-氨酸是d-serine.部分分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分泌分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分分球膜过率是指球膜的过率移植脏移植 移植脏相关概念视频
Glomerular Filtration Rate and its Regulation
3.0K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.0K
Renal Drug Excretion: Glomerular Filtration
340
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
340
Serum Studies: Renal Function Tests
25
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
25
Renal Clearance
1.1K
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
1.1K

