使用细分回归分析的Pseudomonas aeruginosa的抗菌利用率和耐药性:塞尔维亚和八个欧洲国家之间的比较研究
Tanja Tomic1, Martin Henman2, Ivana Tadic3
1Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade, Serbia. tanja.tomic@ymail.com.
International journal of clinical pharmacy
|June 7, 2023
概括
塞尔维亚显示出高抗生素利用率和抗菌素耐药性 (AMR) 在Pseudomonas aeruginosa. 塞夫塔齐,皮佩拉西林/塔扎巴克坦和诺类药物的增加趋势,以及高AMR,需要仔细监测.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 塞尔维亚面临着抗生素利用和抗菌素耐药性 (AMR) 的重大挑战.
- 欧洲抗菌药物耐药性高率是一个日益严重的公共卫生问题.
研究的目的:
- 分析2006年至2020年在塞尔维亚使用关键抗生素 (美罗,塞夫塔齐迪姆,阿米诺糖化物,皮佩拉西林/塔扎巴克坦,诺) 的趋势.
- 评估2013年至2020年在塞尔维亚Pseudomonas aeruginosa中报告的抗菌耐药性 (AMR).
- 将塞尔维亚的抗生素利用率和AMR数据与其他八个欧洲国家进行比较.
主要方法:
- 结点回归分析用于识别抗生素使用趋势和AMR数据.
- 数据来源于国家和国际卫生机构.
- 塞尔维亚与部分欧洲国家进行了比较分析.
主要成果:
- 在塞尔维亚 (2018-2020年) 观察到Pseudomonas aeruginosa中法胺利用和耐药性的显著增加趋势.
- 在塞尔维亚 (2013-2020年) 发现了 Pseudomonas aeruginosa 中对塞夫塔齐迪姆,皮佩拉西林/塔扎巴克坦和诺的抗药性趋势的增加.
- 与其他欧洲国家相比,塞尔维亚表现出高诺基诺和氨基糖化物利用率和高抗 Pseudomonas aeruginosa 耐药率.
结论:
- 由于 Pseudomonas aeruginosa 耐药性的增加,建议仔细监测 piperacillin/tazobactam,ceftazidime 和诺的使用情况.
- 塞尔维亚的抗生素利用率和 Pseudomonas aeruginosa 的AMR 水平相对于其他欧洲国家仍然很高.
- 解决高AMR和利用模式对于塞尔维亚的公共卫生至关重要.
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