高血压中的ACE抑制剂:历史视角和当前见解
Stacey Cutrell1, Ibrahim S Alhomoud1,2, Anurag Mehta3
1Department of Pharmacotherapy & Outcomes Science, Virginia Commonwealth University School of Pharmacy, 410 N. 12th St., Smith Building, 6th floor, Room 660, Richmond, VA, USA.
Current hypertension reports
|June 7, 2023
概括
ангиотензин转化酶 (ACE) 抑制剂对高血压有效,但可能引起副作用. ангиотензин受体阻断剂 (ARBs) 具有类似的疗效,具有更好的耐受性和潜在的较少不良事件.
科学领域:
- 心血管药理学心血管药理学
- 腎臟病學 (nephrology) 是一種醫學.
- 内部医学 内部医学
背景情况:
- ангиотензин转化酶 (ACE) 抑制剂广泛用于高血压 (HTN),心力衰竭和脏疾病.
- 这些药物抑制了ACE,降低了血管激素II的产生,导致血管扩张和降低血压.
- ACE 抑制剂是第一线的HTN治疗,除了利尿剂,通道阻断剂和ARBs.
研究的目的:
- 审查ACE抑制剂用于高血压的发现和开发.
- 为了比较ACE抑制剂与ARBs的疗效,耐受性和安全性.
- 讨论关于在HTN管理中使用ACE抑制剂的当前问题.
主要方法:
- 这是一篇综述性文章,综合了关于ACE抑制剂和ARBs的现有研究.
- 进行了临床试验数据和观察性研究的比较分析.
- 专注于作用机制,临床结果和不良事件概况.
主要成果:
- ACE 抑制剂通过抑制 angiotensin II 合成来降低血压,但布拉迪基宁的积累可以导致血管和咳.
- ангиотензин受体阻断剂 (ARB) 具有较低的血管和咳的风险,因为它们不会抑制ACE.
- 最近的证据表明,ARBs可能提供神经保护性益处,尽管需要进一步的研究.
结论:
- ACE 抑制剂和 ARB 同样被推作为一线 HTN 治疗.
- ARBs对HTN的疗效与ACE抑制剂相似,可改善耐受性.
- 在ACE抑制剂和ARB之间做出选择可能取决于个体患者的个人资料和不良事件的风险因素.
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