合成CTs仅用于MRI的大脑RT治疗:整合固定系统
Siti Masitho1,2, Johanna Grigo3,4, Tobias Brandt3,4
1Department of Radiation Oncology, Strahlenklinik, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Universitätsstraße 27, 91054, Erlangen, Germany. siti.masitho@fau.de.
概括
本研究介绍了一种用于定义合成CT (sCT) 辅助器件的方法,用于MRI-only放射治疗. 这些发现表明,这些设备的剂量计影响是可接受的治疗规划.
科学领域:
- 医学物理 医学物理
- 辐射疗法 辐射疗法
- 医疗成像医学成像
背景情况:
- 只有MRI的放射治疗 (RT) 工作流需要准确的合成CT (sCT) 生成治疗计划 (TP).
- 在MRI采集过程中使用的辅助设备,如固定系统,可能会影响sCT准确性和随后的剂量测量.
- 将这些设备集成到sCT中对于可靠的MRI-onlyRT至关重要.
研究的目的:
- 引入一种在合成CT (sCT) 中定义辅助器件的方法,用于MRI-only放射治疗.
- 评估这些辅助设备对基于sCT的治疗计划 (TP) 的剂量测量影响.
主要方法:
- 在RT设置中获得T1-VIBE DIXON MRI序列用于sCT生成.
- 标记器识别了辅助设备位置,并在TP系统中创建了一个辅助结构模板 (AST).
- 通过重新计算临床计划和模拟sCT上的静态场,评估剂量偏差 (∆D50[%]) 来评估剂量影响.
主要成果:
- 一个最佳的RT口罩定义导致最小的剂量偏差 (∆D50[%]为0.2 ±1.03%的PTV).
- 最大的剂量偏差归因于AST定位不准确性 (最大3.5 ± 2.4%),RT表 (最大3.6 ± 1.2%) 和RT面罩 (最大3.0 ± 0.8%).
- 在大多数光束排列中,没有发现∆D50[%]与光束深度之间的显著相关性.
结论:
- 拟议的方法允许直接集成辅助设备到基于sCT的TP中.
- 在MRI单一工作流程中,辅助设备的剂量计影响被发现处于可接受的范围内.
- 这有助于采用MRI-only放射疗法,因为它解决了必需硬件的影响.
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