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Isolation of Human Islets from Partially Pancreatectomized Patients
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免疫检查点抑制剂诱导的外分胰腺功能衰竭
Deepika Satish1, I-Hsin Lin2, James Flory1
1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
The oncologist
|June 7, 2023
概括
免疫检查点抑制剂 (ICI) 的使用可以导致异位胰腺功能不足 (EPI),这是一个罕见的疾病. 这项研究确定了与ICI相关的EPI的风险因素和临床特征,通常与高血糖和糖尿病有关.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 对免疫检查点抑制剂 (ICI) 使用次要的外分胰腺功能不全 (EPI) 描述不佳.
- 了解ICI相关的EPI对于管理接受免疫治疗的患者至关重要.
研究的目的:
- 确定用ICI治疗的患者EPI的发病率和风险因素.
- 描述ICI相关EPI的临床表现.
主要方法:
- 从2011年1月到2020年7月,对12905名接受ICI治疗的患者进行了回顾性病例控制研究.
- 确定了23名ICI相关EPI患者,并将2:1与对照进行匹配.
- 与ICI相关的EPI被定义为稳态,胰腺酶启动和症状改善.
主要成果:
- 与ICI相关的EPI发生率为每1000人/年1.18人,ICI后的中位数发病时间为390天.
- 常见的EPI病例呈现出流 (100%),体重减轻 (52.2%) 和腹部不适 (39.1%).
- 在39%的EPI患者中,急性胰腺炎的病史先于EPI (OR 18.0),高血糖症发生在39.1%的EPI患者中.
结论:
- 与ICI相关的EPI是与ICI治疗相关的罕见但显著的不良事件.
- 在ICI治疗后出现晚期腹的患者考虑EPI.
- 与ICI相关的EPI通常与高血糖和糖尿病的发展有关.
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