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改变的恐惧引号编码底层的有条件与无条件的刺激启动的记忆更新
Shuai-Wen Teng1, Xin-Rong Wang1, Bo-Wen Du1
1Department of Anatomy and Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Basic Medical Sciences and Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.
Science advances
|June 7, 2023
概括
后检索灭绝通过改变原始的恐惧引文来更新恐惧记忆. 这个过程涉及Engram细胞的重新激活和大脑中的恐惧和灭绝细胞之间的重叠增加.
科学领域:
- 神经科学是一个神经科学.
- 记忆研究 记忆研究
- 恐惧的调节 恐惧的调节
背景情况:
- 恢复后的灭绝,与单独的灭绝不同,可以删除恐惧记忆.
- 在记忆更新过程中,恐惧引擎被修改的确切机制尚不清楚.
研究的目的:
- 为了调查是否在记忆更新过程中,原始恐惧引文的编码模式被重塑或抑制.
- 阐明恩格拉姆细胞激活在受条件刺激和无条件刺激启动的记忆更新中的作用.
主要方法:
- 在记忆更新过程中分析前临界皮层和底侧杏仁体中的恩格拉姆细胞活动.
- 检查记忆更新对恩格拉姆细胞重新激活的依赖性.
- 评估恐惧和灭绝细胞之间的重叠.
主要成果:
- 在记忆更新过程中,在前临床皮质和底侧杏仁体中观察到格拉姆细胞的活性增加.
- 由有条件刺激或无条件刺激启动的记忆更新严重依赖于这些大脑区域的恩格拉姆细胞的重新激活.
- 记忆更新导致了恐惧和灭绝细胞之间更大的重叠,表明了改变的恐惧engram编码.
结论:
- 这项研究为恐惧和灭绝细胞之间的重叠合奏提供了第一个证据.
- 原始恩格拉姆的功能重组是有条件刺激和无条件刺激启动的记忆更新的基础.
- 后检索灭绝积极重塑恐惧记忆引擎,而不是简单地抑制它们.
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