年龄和性别调整后的FT3水平作为生存的新预测因素
David Strich1, Ariel Israel2, Shalom Edri3
1Pediatric Specialists Clinic, Endocrinology and Diabetes, Clalit Health Services, Jerusalem, Israel and Shaare Zedek Medical Center, Jerusalem, Israel.
The Journal of clinical endocrinology and metabolism
|June 7, 2023
概括
较低的自由T3 (FT3) 水平预示着较差的长期存活率,特别是在患有慢性健康状况的个体中. 这一发现强调了FT3作为死亡风险的潜在指标.
科学领域:
- 内分泌学 在内分泌学.
- 临床医学 临床医学
- 大数据分析大数据分析
背景情况:
- 在急性疾病 (甲状腺病综合征) 中观察到较低的自由三甲状腺素 (FT3) 水平,并且还存在慢性形式.
- 甲状腺激素水平,特别是FT3,可以作为各种健康状况的预后标志物.
研究的目的:
- 研究甲状腺功能测试结果与长期存活率之间的关联.
- 为了确定甲状腺激素水平是否可以预测健康和慢性病患者的死亡风险.
主要方法:
- 一项大规模的回顾性研究,利用2008-2014年的甲状腺功能测试,与死亡率数据的电子健康记录联系在一起.
- 甲状腺功能测试结果被转换为年龄和性别调整百分位数 (AGAP).
- 根据最初的AGAP和AGAP在"健康"和"不健康" (患有慢性疾病) 小组中的变化,分析了死亡风险比率.
主要成果:
- 分析包括来自365,965名患者的258,695个甲状腺功能测试.
- 较低的初始FT3AGAP与健康和不健康组的生存率较低显著相关.
- 与具有较高水平的人相比,具有最低FT3AGAP的个体死亡风险比率要高得多,特别是在不健康组 (HR 5.71).
结论:
- 低自由T3 (FT3) 水平,以低年龄和性别调整百分位数 (AGAPs) 表示,预示着长期存活率较低.
- 这种预测关系在患有现有的慢性健康状况的个体中最为明显.
- FT3水平可以作为评估死亡风险的有价值生物标志物.
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