在幻肢疼痛的管理中使用droperidol:案例报告
Madison C Winstead1, Kimberly J Wells2, Gavin T Howington3,4
1University of Kentucky College of Pharmacy, Lexington, Kentucky.
Clinical practice and cases in emergency medicine
|June 7, 2023
概括
德罗佩里多尔有效地管理了截肢者对胺的不良反应的幻肢疼痛 (PLP). 这一案例表明多佩里多尔作为神经病痛综合征的潜在治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
- 疼痛管理 疼痛管理
背景情况:
- 幻肢疼痛 (PLP) 是一种神经病痛状况,影响截肢者没有确定的一线治疗.
- 德罗佩里多尔是一种抗精神病药物,具有多种药理学活性,包括GABA-A调节和阿片类受体强化.
- 它在各种疼痛综合征的非标签用途突出了其潜在的治疗多功能性.
研究的目的:
- 评估德罗佩里多尔在治疗幻肢疼痛 (PLP) 急性恶化的疗效.
- 探索PLP的替代药物治疗方法,当患者对以前的治疗 (胺) 产生不良反应时.
主要方法:
- 一个25岁的男性截肢者的病例报告,患有严重的PLP (10/10疼痛).
- 这位患者曾在PLP治疗中使用过胺,但经历了突发反应.
- 输入静脉的多佩里多尔5毫克被管理,和疼痛水平被评估后的管理.
主要成果:
- 在静脉注射多佩里多尔后,该患者报告说疼痛显著减少.
- 疼痛从10/10下降到3/10在接受德罗皮多尔30分钟内.
- 在治疗后大约15分钟,疼痛明显改善.
结论:
- 这一案例证明了德罗皮多尔在缓解严重幻肢疼痛方面的成功使用.
- 这些发现鼓励进一步研究多佩里多尔作为复杂疼痛综合征的治疗选择.
- 德罗佩里多尔可以作为一种有价值的治疗工具,用于管理截肢者的神经病痛.
更多相关视频
11:29Real-time Video Projection in an MRI for Characterization of Neural Correlates Associated with Mirror Therapy for Phantom Limb Pain
Published on: April 20, 2019
9.8K
03:53Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
1.8K
相关概念视频
Analgesia and Pain Management
669
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
669
Peripheral Artery Disease V: Postoperative Nursing Management
13
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
13
Opioid Analgesics: Synthetic and Semisynthetic Opioids
349
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
349
