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pectin减轻了由PM引起的肺炎反应
Qian Tang1, Dan Shen2, Pengyuan Dai2
1College of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing, Jiangsu 210038, China; Research Center for Livestock Environmental Control and Smart Production, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China.
Ecotoxicology and environmental safety
|June 7, 2023
概括
食中含有的纤维丁可以减少由细颗粒物 (PM2.5) 引起的肺炎. pectin改变肠道细菌并增强有益的短链脂肪酸,提供了一种新方法来对抗PM2.5的健康风险.
科学领域:
- 环境健康 环境健康
- 营养科学 营养科学
- 肺部病理学 肺部病理学
背景情况:
- 暴露于颗粒物 (PM2.5) 是与肺炎相关的重大环境健康问题.
- 正在探索饮食干预措施,以减轻空气污染对健康的不利影响.
研究的目的:
- 调查食中的pectin减轻PM2.5诱导的肺炎的潜力.
- 阐明潜在的机制,包括对肠道微生物群和短链脂肪酸 (SCFA) 生产的影响.
主要方法:
- 鼠被暴露在PM2.5的内内,并补充了他们的饮食中5%的pectin.
- 分析了肺部形态,炎症标志物 (mRNA,MPO,血清蛋白),肠道微生物群组成和SCFA度.
主要成果:
- 素补充剂显著降低了PM2.5诱导的肺炎,由改善的肺形态和减少的炎症标志物证明.
- 饮食中的点氨酸调节了肠道微生物群,增加了像Bacteroidetes这样的有益细菌,并丰富了SCFA产生基因.
- 皮在小鼠中增加了酸盐,酸,丁酸盐和酸盐的度.
结论:
- 饮食中的pectin有效地减轻PM2.5引起的肺炎.
- 保护作用通过调节肠道微生物群和增强SCFA生产来调节.
- pectin代表了一种有前途的饮食策略,以减少与PM2.5暴露相关的健康风险.
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