术前阿片类药物使用与经过乳房重建后的术后并发症的相关性
Michael A Cheah1, Samuel Sarmiento2, Robert P Lesko2
1Department of Plastic and Reconstructive Surgery, Johns Hopkins Hospital, Baltimore, MD 21287, USA; Department of Plastic and Reconstructive Surgery, UT Southwestern, Dallas, TX 75390, USA.
概括
在乳腺重建患者手术前使用阿片类药物显著增加了术后并发症的风险. 这种阿片类药物的使用也可能对手术后患者的生活质量 (QoL) 产生负面影响.
科学领域:
- 整形外科 整形外科 整形外科
- 手术结果研究研究.
- 患者生活质量研究 患者生活质量研究
背景情况:
- 之前的骨科和整形外科研究表明,与手术前使用阿片类药物相关的患者负面结果.
- 手术前阿片类药物使用对乳房重建结果和生活质量 (QoL) 的影响仍在调查中.
研究的目的:
- 调查术前阿片类药物使用与乳腺重建结果之间的关联.
- 评估手术前阿片类药物使用对乳腺重建患者术后生活质量 (QoL) 的影响.
主要方法:
- 审查了乳房重建患者的潜在注册表,以确定手术前的阿片类药物使用.
- 术后并发症在初始和最终重建手术后的60天后进行评估.
- 后勤和线性回归模型分析了阿片类药物使用和并发症/QoL之间的关联,控制共变量. 一个奇平方测试评估了与阿片类药物使用相关的因素.
主要成果:
- 在354名患者中,8.2%的人使用了手术前的阿片类药物. 在阿片类药物使用者中没有发现人口统计或并发症差异.
- 在手术前使用阿片类药物与在60天的随访期间增加术后并发症的几率 (OR:6.28,p=0.006) 和 (OR:8.38,p=0.03) 显著相关.
- 虽然阿片类药物使用者身体和心理健康的RAND36分数下降,但这种变化在统计学上并不显著.
结论:
- 手术前使用阿片类药物与乳房重建患者手术后并发症的可能性更高有关.
- 手术前使用阿片类药物可能会导致术后生活质量 (QoL) 的显著下降.
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