聚米辛B相关的神经毒性:一个简短的案例报告
Izgi Bayraktar1, Burcin Halacli2, Kutay Demirkan3
1Department of Clinical Pharmacy, Hacettepe University Faculty of Pharmacy, Ankara, Turkey izgibayraktar@gmail.com.
概括
聚米辛B可以引起神经毒性,导致麻木和刺痛. 及时停止使用抗生素并转换为胆固醇甲基可以改善耐药性感染患者的症状.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 聚ymyxins (polymyxin B和colistin) 是针对多药耐药细菌感染的最后手段抗生素.
- 这些抗生素带有不良影响的风险,包括毒性和神经毒性.
- 宝曼尼菌 (Acinetobacter baumannii) 是医疗保健相关感染中的重要病原体.
研究的目的:
- 报告一种与多素B相关的神经毒性病例.
- 要突出这种不良影响的临床表现和管理.
- 提高医疗保健专业人员对多素B神经毒性的认识.
主要方法:
- 一名女性患者的病例报告,患有由Acinetobacter baumannii引起的腹部内感染.
- 在Polimyxin B给药后,对神经症状的临床观察.
- 治疗的修改包括停止多素B和启动胆固醇甲酸盐.
主要成果:
- 患者在polymyxin B输液后在四肢,脸部和头部出现感觉障碍 (麻木,刺痛).
- 症状在停止多素B和开始胆固醇甲基酸盐后得到改善.
- 这位患者以前没有任何慢性疾病,这表明药物的直接作用.
结论:
- 聚米辛B可以诱导神经毒性,呈现为外围和骨神经症状.
- 在控制神经毒性方面,早期识别和停止多素B治疗至关重要.
- 对于治疗耐药性感染的临床医生来说,意识到聚米辛B的神经毒性潜力至关重要.
相关概念视频
Local Anesthetics: Adverse Effects
758
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
758
Depolarizing Blockers: Pharmocokinetics
567
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
567


