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翻译Kratom-药物相互作用:从床边到长椅和背后

Rakshit S Tanna¹, Nadja B Cech¹, Nicholas H Oberlies¹

¹Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington (R.S.T., M.F.P.); Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (N.B.C., N.H.O.); Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington (N.B.C., N.H.O., A.E.R., K.E.T., M.F.P.); Departments of Medicinal Chemistry (A.E.R.) and Pharmaceutics (K.E.T.), School of Pharmacy, University of Washington, Seattle, Washington.

Drug metabolism and disposition: the biological fate of chemicals

|June 7, 2023

概括

用于疼痛和阿片类药物戒断的Kratom可能会导致有害的药物相互作用. 它抑制了像CYP2D6和CYP3A这样的关键酶,增加了对其他药物的暴露.

科学领域:

药理学和毒理学药理学和毒理学
自然产品化学化学

背景情况:

克拉是一个来自咖啡家族的植物产品,用于治疗疼痛和阿片类药物戒断.
克拉类类化合物,如米特拉基尼,在过量死亡中被发现,通常涉及多种物质.
人们对 kratom 可能引起药物相互作用存在担忧.

研究的目的:

为了审查Kratom的法律地位,化学,药理学和毒理学.
调查卡拉可能导致与其他药物的药理学相互作用.
为了解决与 kratom 使用有关的公共卫生问题.

主要方法:

综合体和临床数据的综述.
对kratom对细胞P450 (P450) 酶活性的影响的分析.
评估P-糖蛋白介导的流体活动.

主要成果:

克拉及其类化合物抑制了CYP2D6,CYP3A和P-糖蛋白.
这些抑制作用可能会增加系统性接触与药物共用药物.
多重中毒和体外-体内外提取表明有显著的相互作用潜力.

结论:

克拉托姆可以加速药理动力学药物相互作用.
需要使用体外研究,临床试验和药理动力学建模进行进一步的评估.
了解kratom药物相互作用对于公共卫生和安全使用至关重要.

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