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Updated: Jan 18, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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通过细胞内激动剂激活B1类GPCR

Kazuhiro Kobayashi1, Kouki Kawakami2, Tsukasa Kusakizako1

  • 1Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan.

Nature
|June 7, 2023
PubMed
概括

研究人员在G蛋白结合受体 (GPCR) 中发现了一种新的细胞内结合口袋. 这一发现揭示了偏向激动剂如何选择性地激活信号通路,为药物开发提供了新的途径.

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