皮里丁-4-甲胺甲酸盐单水合物
Rüdiger W Seidel1, Tsonko M Kolev2
1Institut für Pharmazie, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle (Saale), Germany.
IUCrData
|June 8, 2023
概括
这项研究详细介绍了pyridin-4-ylmethanaminium chloride monohydrate 的晶体结构. 这项研究揭示了不同的阴离子构造和固态中复杂的键网络.
科学领域:
- 晶体学 晶体学是指结晶学.
- 固态化学 固态化学
- 材料科学是一种材料科学.
背景情况:
- 了解有机盐的结构性质对于开发新材料至关重要.
- 化-4-甲氨酸单酸盐是一种化合物,在各种化学领域具有潜在的应用.
- 详细的结构分析提供了对分子间相互作用和晶体包装的洞察力.
研究的目的:
- 为了确定pyridin-4-ylmethanaminium甲酸单酸盐的晶体结构.
- 为了分析4-picolyl-ammonium离子和酸盐离子的构成.
- 为了研究固态中的键网络和超分子组合.
主要方法:
- 单晶X射线衍射被用来阐明晶体结构.
- 分析了结晶学数据,以确定空间组,单元细胞参数和原子坐标.
- 用几何标准识别和表征结相互作用.
主要成果:
- 皮里丁-4-甲氨酸甲酸单水化合物结晶在单临床系统中,空间组P21/n,Z'=2.2.
- 观察到两种不同的4 - picolyl-ammonium离子,具有不同的构造.
- 一个由N-HO,O-HN和O-HO气键组成的三周期超分子网络被确定.
结论:
- 已经成功确定了pyridin-4-ylmethanaminium甲酸单酸盐的晶体结构.
- 这项研究突出了有机离子体的构造多样性和固态中复杂的键.
- 这些发现有助于理解有机盐中的结构性质关系.
相关概念视频
Preparation of Amines: Alkylation of Ammonia and Amines
3.5K
Alkylation is one of the methods used to prepare amines. Direct alkylation of ammonia or a primary amine with an alkyl halide gives polyalkylated amines along with a quaternary ammonium salt through successive SN2 reactions. This process of making the quaternary salt through the direct alkylation method is called exhaustive alkylation.
Each alkylation step makes the nitrogen center more nucleophilic, which triggers successive alkylations until a quaternary ammonium salt is formed. Considering...
Each alkylation step makes the nitrogen center more nucleophilic, which triggers successive alkylations until a quaternary ammonium salt is formed. Considering...
3.5K
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism
3.9K
Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
3.9K
Structure of Amines
2.6K
The hybridized nitrogen atom in amines possesses a lone pair of electrons and is bound to three substituents with a bond angle of around 108°, which is less than the tetrahedral angle of 109.5°. However, the C–N–H bond angle is slightly larger at 112°, with a carbon–nitrogen bond length of 147 pm. This carbon–nitrogen bond length of of amines is longer than the carbon–oxygen bond of alcohols (143 pm) but shorter than alkanes’...
2.6K
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
3.3K
Nitrous acid and nitric acids are two types of acids containing nitrogen, among which nitrous acid is weaker than nitric acid. Nitrous acid with a pKa value of 3.37 ionizes in water to give a nitrite ion and the hydronium ion.
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by...
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by...
3.3K
Acid Halides to Amides: Aminolysis
2.9K
Aminolysis is a nucleophilic acyl substitution reaction, where ammonia or amines act as nucleophiles to give the substitution product. Acid halides react with ammonia, primary amines, and secondary amines to yield primary, secondary, and tertiary amides, respectively.
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
In the first step of the aminolysis mechanism, the amine attacks the carbonyl carbon of the acyl chloride to form a tetrahedral intermediate. In the second step, the carbonyl group is re-formed with the elimination of a chloride...
2.9K
Washing, Drying, and Ignition of Precipitates
980
After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
980


