对直肠状细胞癌的治疗范式和预后因素分析
Rui Liu1,2, Jiahui Zhang3, Yinjie Zhang2
1Department of Clinical Medicine, Southwest Medical University, Luzhou, China.
Frontiers in oncology
|June 8, 2023
概括
罕见的直肠状细胞癌 (rSCC) 的治疗方法因阶段而异. 建议在第一阶段进行放射治疗或手术,而在第二和第三阶段建议进行化学放射治疗.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 直肠状细胞癌 (rSCC) 是一种罕见的直肠癌亚型,没有确立的治疗共识.
- 这项研究解决了对RSCC的临床治疗范式和预后工具的需求.
研究的目的:
- 建立直肠状细胞癌的临床治疗范式.
- 开发一种预后性诺姆图,用于预测RSCC患者的预后结果.
主要方法:
- 利用了监测,流行病学和最终结果 (SEER) 数据库,用于2010-2019年间诊断的患者.
- 采用卡普兰-梅尔生存分析和考克斯回归来确定生存益处和独立的预后因素.
- 使用Harrell的协同指数,校准曲线和决策曲线分析验证了名ogram.
主要成果:
- 生存分析显示,对于1期rSCC的癌症特异性生存率 (CSS) 在放射治疗 (RT),化疗放射治疗 (CRT) 或手术中没有显著差异.
- 在第2阶段 (手术,RT,CRT) 和第3阶段 (CRT,CRT加手术,不接受治疗) rSCC中观察到显著的CSS差异.
- 确定年龄,婚姻状况,TNM阶段,PNI,瘤大小,RT,化疗 (CT) 和手术作为CSS的独立风险因素.
结论:
- 建议RT或手术治疗第一阶段rSCC,以及CRT治疗第二和第三阶段rSCC.
- 确定RSCC中CSS的关键独立风险因素,包括人口,临床和治疗变量.
- 开发了一个具有卓越预测效率和rSCC临床应用价值的预后模型.
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