长期COVID的认知障碍及其与炎症标志物的持续失调相关
Rodolfo Furlan Damiano1, Cristiana Castanho de Almeida Rocca1, Antonio de Pádua Serafim2
1Departamento e Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.
Frontiers in immunology
|June 8, 2023
概括
社会人口学因素,而不是临床或炎症标志物,影响了COVID-19后的长期认知结果. 这项研究强调了个人特征在病毒后认知健康中的重要性.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- COVID-19幸存者,特别是中度至重度疾病患者,经常报告持续的认知缺陷,通常称为"脑雾".
- 了解SARS-CoV-2感染后导致长期认知障碍的因素对于患者管理和公共卫生策略至关重要.
研究的目的:
- 研究社会人口学,临床和生物因素对经历中度至重度COVID-19的个体长期认知结果的影响.
主要方法:
- 评估了710名成年COVID-19幸存者在医院出院6-11个月后使用全面的认知电池,精神病学评估和临床/实验室评估.
- 专注于28种细胞因子和炎症标志物的小组,以及疾病严重程度指标.
- 采用了一系列推断统计方法,包括LASSO回归,以确定认知障碍的预测因素.
主要成果:
- 36.1%的参与者报告了主观认知投诉,其中14.6%的人经历了严重的影响.
- 多变量分析将一般认知与社会人口统计学因素联系起来:性别,年龄,种族,教育,并发症,虚弱和身体活动.
- 最初的双变体分析表明,特定细胞因子 (例如G-CSF,IL-6,TNF-Beta) 与认知功能之间存在关联,但这些并未得到LASSO回归包括所有变量的支持.
结论:
- 社会人口统计学特征似乎在保护或促进SARS-CoV-2感染后认知障碍方面发挥着重要作用.
- 该研究的结果不支持临床状态或炎症标志物在解释COVID-19后认知缺陷方面在急性感染期间或长期内发挥重要作用.
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