用富含大麻素 (CBD) 的大麻提取物再生头发 - 一个案例系列
Gregory L Smith1, John Satino2
1Medical Director, Medical Life Care Planners, St. Petersburg, FL, USA.
Cannabis (Albuquerque, N.M.)
|June 8, 2023
概括
大麻二醇 (CBD) 显示出对治疗雄性发育性脱发症 (AGA) 的承诺,这是最常见的脱发. 一项为期六个月的研究发现,局部CBD显著增加了头发的再生,没有报告任何不良影响.
科学领域:
- 皮肤病学和头发生物学
- 内类大麻素系统研究研究
背景情况:
- 雄激素性脱发症 (AGA) 是脱发的普遍原因,治疗选择有限.
- 内分泌大麻素系统 (ECS),包括CB1受体,在毛囊调节中起着至关重要的作用.
- 大麻二醇 (CBD) 调节CB1受体并影响头发生长途径,如Wnt信号传递.
研究的目的:
- 为了研究局部大麻素 (CBD) 在促进雄激素性脱发症 (AGA) 患者头发再生的疗效.
- 评估CBD与现有脱发治疗的安全性和潜在协同效应.
主要方法:
- 一项为期六个月的研究涉及35名患有AGA的受试者.
- 参与者每天使用一种含有3-4毫克CBD的局部麻油配方.
- 在治疗期前后进行了头发计数,以评估变化.
主要成果:
- 在六个月后,观察到头发数量平均增加了93.5%,这是统计学上显著的.
- 所有受试者都经历了一定程度的头发再生.
- 男性的结果略有好于女性,顶部区域比部区域更有改善.
- 在研究期间没有报告任何不良影响.
结论:
- 局部CBD在促进安卓发症的头发再生方面表现出显著的有效性.
- CBD的新机制为与费纳斯特和米诺克西迪尔的联合治疗提供了潜力,可能产生协同效应.
- 对CBD的剂量依赖性作用和受体相互作用 (CB1,TRPV1,TRPV4) 的进一步研究是有必要的.
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