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相关概念视频

Vision01:24

Vision

53.6K
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
53.6K
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

1.7K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.7K

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相关实验视频

Updated: Jul 27, 2025

Vision Training Methods for Sports Concussion Mitigation and Management
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Vision Training Methods for Sports Concussion Mitigation and Management

Published on: May 5, 2015

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从愿景到最佳实践:评估

Anthony J F Reardon1, Reza Farmahin1, Andrew Williams2

  • 1Existing Substances Risk Assessment Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, Canada.

Frontiers in toxicology
|June 8, 2023
PubMed
概括
此摘要是机器生成的。

这项研究验证了使用高通量转录组学 (HTTr) 进行化学风险评估的新方法. 它表明这些转录基因起点 (tPODs) 对人类健康有保护作用,尽管需要解决数据差距.

关键词:
这些是NAMs.基准剂量 (BMD) 建模模型化学安全 化学安全 化学安全在体外到体外抽取 (IVIVE)新方法方法新方法方法.转录组学 转录组学是指转录组学.

更多相关视频

A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision
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A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision

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Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
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Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

Published on: April 11, 2025

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相关实验视频

Last Updated: Jul 27, 2025

Vision Training Methods for Sports Concussion Mitigation and Management
12:54

Vision Training Methods for Sports Concussion Mitigation and Management

Published on: May 5, 2015

17.5K
A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision
09:29

A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision

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Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

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科学领域:

  • 毒理学 毒理学 毒理学
  • 计算生物学 计算生物学
  • 风险评估 风险评估

背景情况:

  • 增加化学品生产需要有效的风险评估方法.
  • 传统的动物试验在人类的相关性和能力上是有限的.
  • 需要新的方法来满足对毒性数据的监管要求.

研究的目的:

  • 增加对化学风险评估新方法 (NAM) 的信心.
  • 确定当前毒性测试策略中的数据缺口和局限性.
  • 证明高通量转录组学 (HTTr) 的实用性,用于推导实际的终点.

主要方法:

  • 将统一的工作流应用于6个基因表达数据集 (117种化学物质,3种细胞类型).
  • 使用基准度建模确定转录基因起点 (tPODs).
  • 在体外将tPOD转化为人体相关的同等剂量 (AED),使用高通量毒动力学.

主要成果:

  • 在体外的tPOD产生的AED通常低于传统的POD (更保守),这表明对人类健康的保护.
  • 较长的暴露时间和3D细胞模型降低了tPOD值,表明化学效能更高.
  • 七种化学品被标记为需要进一步危险评估的异常值.

结论:

  • 调查结果支持使用从HTTr衍生出的tPODs进行监管风险评估.
  • 发现的数据缺口,包括暴露时间和细胞模型类型,需要进一步调查.
  • 解决这些差距将为在风险评估应用中采用tPODs建立信心.