对心力衰竭进行同步腹膜刺激,使用VisONE系统减少左心室喷射率:一项针对扩大人口的首次患者研究
Ana Jorbenadze1, Lee R Goldberg2, Tamaz Shaburishvili1
1Heart and Vascular Clinic, Tbilisi, Georgia.
Structural heart : the journal of the Heart Team
|June 8, 2023
概括
同步腹膜刺激 (SDS) 在减少喷射率的患者中安全地改善了心力衰竭的结果. 这种新疗法在一年内增强了运动能力和生活质量.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 医疗器械 医疗器械
背景情况:
- 同步腹膜刺激 (SDS) 调节胸内压力,以改善心力衰竭中的心脏功能,减少射出率 (HFrEF).
- 这项研究评估了使用各种植入技术在扩大患者队列中SDS的安全性和1年有效性.
研究的目的:
- 评估SDS在接受指南导向治疗的有症状的HFrEF患者的安全性和有效性.
- 评估结果,包括12个月的不良事件,生活质量,心声回声和运动能力.
主要方法:
- 招募了19名男性HFrEF患者,并使用三种不同的手术方法进行了SDS植入.
- 患者被监测不良事件,并评估生活质量 (SF-36 QOL),6分钟的走廊距离和心声学参数在3,6和12个月.
主要成果:
- 这三种植入技术均成功 (100%),没有与手术或SDS相关的不良事件.
- 在6分钟走廊距离 (p=0.002) 和SF-36 QOL物理 (p=0.004) 和情绪 (p=0.001) 尺度上观察到显著改善.
- 左心室末缩体积下降 (p=0.04),而N-终端亲B型尿素和左心室喷射分数显示出非显著的改善趋势.
结论:
- 在HFrEF患者中,可以使用替代植入方法安全地输送SDS.
- 这项研究表明,在一年的随访期间,有可能改善患者的治疗结果.
- 需要进行更大规模的随机试验来证实这些初步发现.
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